支气管哮喘患者支气管舒张试验指标与疗效关系的研究  

Study on the relationship between the bronchial relaxation test index and the curative effects in patients with bronchial asthma

作　　者：刘泽英[1] 刘双[1] 朱晨曦[1] 李杰[1] 樊静[1] 张伶[1] 

机构地区：[1]首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所呼吸内科,北京100029

出　　处：《心肺血管病杂志》2013年第5期569-572,共4页Journal of Cardiovascular and Pulmonary Diseases

摘　　要：目的:研究支气管哮喘患者支气管舒张试验指标与疗效的关系。方法:支气管哮喘患者经支气管舒张试验检查结果阳性者42例,通过对比支气管舒张试验指标与峰流速变异率及哮喘控制测试(ACT),探讨其与治疗效果的关系。结果:①肺功能舒张试验第1秒用力呼气容积(FEV1)改善率、舒张后FEV1值、PEF改善率与治疗前ACT相关(Р<0.05);FEV1改善绝对值、舒张前FEV1值、治疗前峰流速PEF改善率与治疗前ACT无相关性(Р>0.05)。②以治疗前后ACT改善值为判断指标,治疗前PEF改善率与其显著相关(Р<0.01);FEV1改善率、FEV1改善绝对值、舒张后FEV1值与其有相关性(Р<0.05);而舒张前FEV1值、治疗前峰流速PEF改善率与其无相关性(Р>0.05)。③以治疗后峰流速仪测定PEF变异率为判断标准,治疗前肺功能PEF改善率、峰流速仪PEF改善率、舒张试验FEV1改善绝对值与其显著相关(Р<0.01);舒张试验FEV1改善率与其有相关性(Р<0.05);而舒张试验中吸入沙丁胺醇前后FEV1值与其无相关性(Р>0.05)。④以治疗前后ACT改善值及治疗后峰流速仪测定PEF变异率同时作为判断标准,治疗前PEF改善率与其显著相关(Р<0.01);FEV1改善率、FEV1改善绝对值与其相关(Р<0.05)。结论:治疗前支气管舒张试验中PEF改善率、FEV1改善率、FEV1改善绝对值是可以对治疗效果有较好的判断。Objective：To research the relationship between the bronchial relaxation test index and the curative effects in patients with bronchial asthma. Methods ： Research 42 cases of patients with positive results of the bronchial relaxation test, by comparing the bronchial test index, PEF and ACT, and explore the relation- ship between the test index and the curative effects. Results： FEV1 improvement rate of bronchial relaxation tests, FEV1 values after bronchial relaxation tests and PEF improvement rate have the relationship with ACT re- suhs before treatment （P 〈 0. 05 ） ; FEV, improvement absolute value, FEV1 value before bronchial relaxation test and PEF improvement rate before treatment have no relationship with ACT results before treatment （P 〉 0, 05）. Considering ACT improvement value based on pre-treatment and post-treatment, PEF improvement rate has significant relationship with it（P 〈 0. 01 ） ; FEVI improvement rate, FEV improvement absolute value and FEVl value after bronchial relaxation test have the relationship with it（P 〈 0. 05 ） ; FEV before the test and PEF improvement rate before treatment have no relationship with it （P 〉 0.05）. （3） Considering PEF variation rate, PEF improvement rate before treatment, PEF improvement rate and FEV improvement absolute value have significant relationship with it （P 〈 0. O1 ） ; FEV1 improvement rate has relationship with it （ P 〈 0. 05 ） ;FEV1 values before and after inhaling salbutamol have no relationship with it （P 〉 0. 05 ）. （4） Considering ACT improvement value based on pre-treatment and post-treatment and PEF variation rate at the same time, PEF im- provement rate before treatment have the significant relationship with them （ P 〈 0.01 ） ; FEV1 improvement rate and FEV1 improvement absolute value has relationship with them （ P 〈 0. 05 ）. Conclusion： PEF improvement rate of the bronchial relaxation test before treatment, FEV1 improvement rate and FEV1 improvement absolute value can be taken

关 键 词：支气管哮喘 舒张试验指标 疗效 

分 类 号：R56[医药卫生—呼吸系统]