三个新大环草酰胺Ni(Ⅱ)配合物配体的合成、结构和DNA切割活性研究  

Syntheses, Structures and DNA-cleavage of Three New Macrocyclic Oxamido Ni(Ⅱ) Complex Ligands

作　　者：丁贝贝[1] 李尚浩[1] 马志刚[1] 郝鹏鹏[2] 李孝增[1] 朱莉娜[1] 

机构地区：[1]天津大学化学系,天津300072 [2]天津大学仁爱学院化工系,天津301636

出　　处：《南开大学学报（自然科学版）》2013年第3期1-9,共9页Acta Scientiarum Naturalium Universitatis Nankaiensis

基　　金：国家自然科学基金(20801040)

摘　　要：合成了3个新的大环草酰胺Ni（Ⅱ）单核配合物NiL1（1），NiL2·CH3CH2OH（2）和NiL3·1．25H2O（3）．由于羟基和草酰胺基团的氧原子都能够与金属离子配位，因此，NiL1-3可以用作构筑同多核和异多核配位化合物的配合物配体．X-射线单晶结构分析表明，每个大环配体的4个N原子与Ni（Ⅱ）配位，构成变形的平面正方形配位环境；Ni—N键的长度都非常短，表明3个大环配体中所有氮原子的配位能力都很强．1～3中的醇羟基使羟自由基淬灭，从而抑制了配合物切割DNA的活性．Three new macrocyclic oxamide complexes, NiL1（1）, NiL2. CH3CH2OH （2） and NiL3· 1.25H20 （3） have been synthesized. The oxygen atoms of oxamido group and the hydroxyl group can coordinate to metal ions, therefore NiL1-~ can be used as complex ligands to construct homo- and hetero-metallic polynuclear coordination compounds. X-ray single crys- tal structure analysis indicates that four N atoms of each macrocyclic ligand coordinate to a Ni （Ⅱ ） ion to form a distorted square planar geometry. The Ni--N bonds in the three complexes are very short, suggesting that the coordinating capabilities of all nitrogen atoms are very strong. DNA cleavage activities of 1--3 were inhibited by the alcoholic hydroxyl groups due to their hydroxyl radical-scavenging activities.

关 键 词：晶体结构 大环配合物 金属配合物配体 

分 类 号：O614[理学—无机化学]