p-eIF4E和p-Mnk1在头颈鳞状细胞癌中的表达及临床意义  

Clinical significance of the expression of p-eIF4 E and p-Mnk1 in HNSCC

作　　者：李姣[1] 谢贵元[2] 李美蓉[1] 范松青[1] 

机构地区：[1]中南大学湘雅二医院病理科,湖南长沙410011 [2]中南大学湘雅二医院肿瘤科,湖南长沙410011

出　　处：《中国耳鼻咽喉颅底外科杂志》2013年第5期399-402,共4页Chinese Journal of Otorhinolaryngology-skull Base Surgery

基　　金：国家自然科学基金资助(81071820)

摘　　要：目的探讨磷酸化真核细胞翻译起始因子4E(p-eukaryotic translation initiation factor 4E,peIF4 E)和磷酸化MAPK作用激酶1(p-MAP kinase integrating kinase,p-Mnk1)在头颈鳞状细胞癌(head and neck squamous cell cancer,HNSCC)中的表达及其临床意义。方法 HNSCC组织芯片结合免疫组化S-P法检测p-eIF4E和p-Mnk1在60例HNSCC和35例癌旁组织中的蛋白表达,分析两者表达与HNSCC临床病理特征的相关性。结果 p-eIF4E和p-Mnk1在HNSCC中的阳性表达率显著高于癌旁组织(P<0.01),p-eIF4 E的阳性表达率与HNSCC的分化程度、临床分期显著相关(P<0.05);有淋巴结转移HNSCC的p-Mnk1阳性表达率显著高于无淋巴结转移者(P<0.05)。HNSCC组织中p-eIF4 E和p-Mnk1表达呈显著正相关(r=0.375,P=0.005)。结论HNSCC组织中p-eIF4E和p-Mnk1异常表达与HNSCC的临床进展和浸润转移相关,两者在肿瘤发生发展过程中有协同作用。Objective To study the expression of p-eIF4 E and p-Mnk 1 in the head and neck squamous cell carcinoma （HNSCC） and its clinical significance. Methods Expression of p-eIF4E and p-Mnk 1 was detected in 60 samples of HNSCC and 35 of peri-cancer tissues by tissue microarray immunohistochemical S-P method. Results The positive expression rates of p-eIF4E and p-Mnkl in HNSCC were significantly higher than those of peri-cancer tissues （both P 〈 0.01 ）. The expression of p-eIF4E was correlated with pathological grading and clinical stages of HNSCC （ P 〈 0.05 ）. The expression rate of p-Mnkl in HNSCC with lymphatic metastasis was significantly higher than that without metastasis （P 〈 0.05 ）. In addition, the expression of p-eIF4E was positively correlated with that of p-Mnk 1 in HNSCC （ r =0. 361 , P = 0. 005 ） . Conclusions The abnormal expression of p-eIF4 E and p-Mnk 1 is related to the development, invasion and metastasis of HNSCC. Co-expression of p-eIF4E and p-Mnkl has a possible synergistic action that may promote the carcinogenic process of HNSCC.

关 键 词：p-真核细胞翻译起始因子4E p-MAPK作用激酶1 头颈鳞状细胞癌 癌旁组织 

分 类 号：R34[医药卫生—基础医学] R739.91