胆囊收缩素与神经损伤的修复  

Cholecystokinin and nerve repair

作　　者：陈宣煌[1] 胡荔斌[1] 李荣议[1] 蔡涵华[1] 

机构地区：[1]莆田学院附属医院骨科,福建省莆田市351100

出　　处：《中国组织工程研究》2013年第41期7323-7328,共6页Chinese Journal of Tissue Engineering Research

基　　金：福建省教育厅A类科技面上项目(JA11212);福建省莆田市医学科技课题计划2012S03(4)~~

摘　　要：背景:在过去20余年中,围绕着胆囊收缩素的临床应用以及在神经损伤中的作用进行了广泛的研究。目的:探讨胆囊收缩素在神经损伤后的作用及其可能的作用机制。方法:通过检索近年来关于胆囊收缩素的生物学特性及其在神经系统中的生物学作用相关文献,从动物实验的细胞、器官水平对这些相关研究成果作回顾性分析,总结胆囊收缩素在神经损伤后的作用及其可能的作用机制等方面的研究。结果与结论:胆囊收缩素及其受体在体内的广泛分布,其在生理及病理状态下的作用也复杂多样,但对胆囊收缩素的神经保护作用的研究还不充分,大部分实验还仅局限于对现象的观察,胆囊收缩素对神经保护的作用机制尚值得深入研究,为最终应用于临床奠定基础。BACKGROUND： In the past 20 years, cholecystokinin in clinical application and nerve repair has been extensively studied. OBJECTIVE： To explore the role of cholecystokinin in nerve repair and its possible mechanism of action. METHODS： Relevant research results were retrospectively analyzed at the cell and organ levels through retrieving recant literatures concerning the biological characteristics of cholecystokinin and its biological role in the nervous system. Then, we summarized the effect of cholecystokinin after nerve injury and its possible mechanism of action. RESULTS AND CONCLUSION： Cholecystokinin and its receptors are widely distributed in the body, and under physiological and pathological conditions, their roles were complex and diverse. However, studies addressing the neuroprotective effect of cholecystokinin are not sufficient, most of which are limited to phenomenon observation. Neuroprotective mechanism of cholecystoklnin is still worthy of further studies, which can provide the basis for the clinical application.

关 键 词：组织构建 组织构建学术探讨 胆囊收缩素 神经损伤 神经系统 神经再生 神经细胞老化 神经元 神经生长因子 神经营养因子 神经递质 保护 修复 省级基金 

分 类 号：R318[医药卫生—生物医学工程]