中晚期宫颈癌伴绝经患者综合治疗的临床观察  

Clinical observation of the comprehensive therapy for mid-and late-term cervical cancer in postmenopausal patients

作　　者：孙晓伟[1] 郭海[1] 解春生[1] 陈奇[1] 王媛媛[1] 方砚华[1] 

机构地区：[1]北京市房山区第一医院,北京102400

出　　处：《中国骨质疏松杂志》2013年第10期1053-1055,共3页Chinese Journal of Osteoporosis

摘　　要：目的本研究通过应用三维适形放疗加热疗及抗骨质疏松药物的综合治疗100例宫颈癌伴绝经患者,探讨综合治疗的可行性和优越性,以改进临床工作,提高肿瘤患者的生活质量和疗效。预防和延迟骨质疏松的发生。方法将100例宫颈癌患者分为三维适形放疗加热疗及抗骨质疏松药物组50例(R+H+OP)和单纯三维适形放疗组50例(R)。治疗过程中观察不良反应,治疗结束后一个月评价疗效。结果宫颈癌伴绝经患者与对照组相比BGP、BMD均明显降低,P<0.01、P<0.001;AKP升高,两者比较有明显差异,P<0.05;血Ca、P无明显变化,P>0.05。结论对中晚期宫颈癌伴绝经患者用三维适形放疗加热疗及抗骨质疏松药物综合治疗的同时,测定BGP、BMD、AKP等具有临床价值。为进一步提高患者的生活质量必须采取适当的治疗和预防措施,以降低恶性肿瘤的骨转移及其引起的骨破坏,有针对性的选择适形放疗热疗及抗骨质疏松药物等同时对肿瘤引起的骨破坏或继发病症进行治疗和预防,以减轻症状和防止严重并发症的发生。Objective To investigate the feasibility and the advantage of comprehensive therapy, which composed of 3D CRT, hyperthermia, and anti-osteoporosis medicine, for cervical cancer in 100 patients, to improve clinical work and the quality of life of the patients, and to prevent and delay the occurrence of osteoporosis. Methods A total of 100 cervical cancer patients were divided into 2 groups （n = 50, each）. Patients in Group A were treated with three dimensional conformal radiotherapy, hyperthermia, and drug resistance of bone hydrophobic （A： R ＋ H ＋ OP） , while patients in Group B were just treated with three-dimensional conformal radiotherapy （B： R）. The adverse reactions of the treatment were observed. The efficacy was evaluated 1 month after the treatment. Results The level of BGP and BMD in Group A was significantly lower than that in Group B （P 〈 0. 01, P 〈 0. 001 ）. The AKP level increased （P 〈 0.05 ）. No significant difference of calcium and phosphorus was observed between 2 groups （ P 〉 0. 05 ）. Conclusion Targeted selection of comprehensive therapy, including conformal radiotherapy, hyperthermia, and anti-osteoporosis medicine, can prevent and treat the bone destruction and secondary diseases caused by the tumor, which can relieve the symptoms and prevent the occurrence of serious complications.

关 键 词：宫颈癌 三维适形放疗 热疗 骨质疏松 

分 类 号：R45[医药卫生—治疗学]