Zn-MOF模板法制备ZnO/C/SNTs及其药物缓释性能  

Synthesis of ZnO /C /SNTs Using Zn-MOF as Template and Their Drug Delivery Ability

作　　者：李宗群[1] 汪艾[1] 郭春燕[1] 胡文娜[1] 邰燕芳[1] 

机构地区：[1]蚌埠学院应用化学与环境工程系,蚌埠233000

出　　处：《高等学校化学学报》2013年第11期2470-2477,共8页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20971001);安徽省教育厅重点自然科学基金(批准号:KJ2012A193)资助

摘　　要：采用超声法一步合成了SiO2包覆金属-有机骨架[Zn6(OH)3(BTC)3(H2O)3]·7H2O(Zn-MOF,BTC=1,3,5-均苯三羧酸根)纳米晶,在N2保护下,热解Zn-MOF@SiO2获得了ZnO/C/SNTs复合物,进而与布洛芬(HIBU)反应合成药物组装体Zn(IBU)2/C/SNTs.通过透射电子显微镜(TEM)、傅里叶变换红外光谱仪(FTIR)、高分辨透射电子显微镜(HRTEM)和X射线衍射仪(XRD)对样品的结构和形貌进行表征.结果显示,Zn-MOF@SiO2呈棒状,具有清晰的核/壳结构,形貌单一,分散性良好.煅烧后SNTs结构稳定,形貌基本不变.载药实验表明,药物组装体的载药量为752 mg/g,并具有良好的pH响应性能.Nanocrystallines of metal-organic framework[Zn6(OH)3(BTC)3(H2O)3]·7H2O(Zn-MOF,BTC = benzene-1,3,5-tricarboxylate) coated with SiO2nanotubes( SNTs) were synthesized by a simple onestep ultrasonic route. ZnO / C / SNTs hybrid composites were produced by thermolysis of Zn-MOF / SNTs in N2environments,then the drug assemblies of Zn( IBU)2/ C / SNTs were synthesized by the reaction of ibuprofen(HIBU) and ZnO/C/SNTs. The morphology and structure of nanoparticle were characterized by transmission electron microscopy( TEM),high resolution transmission electron microscopy( HRTEM),Fourier transform infrared spectrometry(FTIR) and X-ray diffraction(XRD). The results show that the Zn-MOF/SNTs have clear core-shell structure with rod-like shape,same-sized and well-dispersed. The as-prepared SNTs have better structure stability and the morphologies remain unchangeable after calcination. The results demonstrated that the drug loading was about 752 mg / g,and the drug assemblies had an excellent pH responsive behavior.

关 键 词：金属-有机骨架 核 壳结构 二氧化硅纳米管 缓释 

分 类 号：O614[理学—无机化学]