原发性干燥综合征并发血液系统损害与免疫学指标相关性分析  

The study on the relationship between immunologic markers and hematological damages of primary Sjogren's syndrome

作　　者：冯斯斯[1] 钟白云[1] 郭婧婧[1] 邓辉[1] 张秋焕[1] 

机构地区：[1]中南大学湘雅医院检验科,湖南长沙410008

出　　处：《中国现代医学杂志》2013年第25期44-46,共3页China Journal of Modern Medicine

摘　　要：目的探讨原发性干燥综合征(pSS)血液系统损害情况及其免疫学指标的改变。方法研究86例pSS患者血常规、抗核抗体、抗可溶性抗原、补体及免疫球蛋白等检测结果,分析血液系统改变时免疫学指标的改变。结果 86例pSS患者中出现血液系统改变的有58例(67.4%),其中贫血46例(53.5%),血小板减少16例(18.6%),白细胞减少20例(23.3%)。有血液系统损害的pSS患者出现抗SSA抗体阳性率高于无血液系统损害组,补体明显低于无血液系统损害组。结论血液系统损害在pSS中多见,以贫血最为常见,抗SSA抗体与补体可能与pSS的血液系统损害存在相关性。[ Objective ] To explore the characteristics of hematological and immunologic changes in patients with primary Sjogren＇s syndrome（pSS）. [ Methods ] The blood routine,antinuclear antibody,Extractable nuclear antigen, complements and immunoglobulin of 86 cases with pSS were analyzed, the relation between immum）h）gic markers and hematological damages wereexplored. [Results] The data showed that 58 patients（67.4%） among 86 cases had hematological changes, of which 46 cases （53.5%） were anaemia, 16 cases （18.6%） were thrombocytopenia, and 20 （23.3%） were leneopenia. The positive incidence of antiRo （SSA） antibodies in patients with hematological damages was significantly higher than that in patient with normal blood cells, complement was lower than the non-hematological system damage group. [Conclusion] Hematological damages are common, and anemia is the most common finding. AntiRo（SSA） and complement may be closely associated with the hematological involvement.

关 键 词：干燥综合征 血液系统 补体 抗SSA抗体 

分 类 号：R593.2[医药卫生—内科学] R446.62[医药卫生—临床医学]