RAD51 135G>C位点多态性与乳腺癌发病风险Meta分析  

RAD51 135G > C polymorphism and risk of breast cancer: a meta-analysis

作　　者：秦洁洁[1] 武珍珍[1] 张尚书[1] 吕恭进[1] 杨君霞[1] 宋春花[1,2] 

机构地区：[1]郑州大学公共卫生学院流行病学教研室,河南郑州450001 [2]河南省肿瘤流行病学重点实验室

出　　处：《中国公共卫生》2013年第11期1702-1706,共5页Chinese Journal of Public Health

基　　金：国家自然科学基金(81202278)

摘　　要：目的 分析RAD51 135G〉C位点多态性与乳腺癌的发病风险关系。方法 检索中外数据库,获得有关RAD51 135G〉C位点多态性与乳腺癌发病风险的病例对照研究资料进行Meta分析。结果 共纳入文献15篇,累计乳腺癌病例12 717例,对照12 088例,与野生基因型GG相比,CC、GC和（GC＋CC）合并的OR值（95%CI）分别为1.45（1.13-1.86）、0.95（0.75-1.20）、1.08（0.91-1.27）。结论 RAD51 135G〉C位点纯合突变基因型CC是乳腺癌发病的危险因素,未发现RAD51 135G〉C位点GC和（GC＋CC）基因型与乳腺癌的发病风险有关。Objective To explore the association between RAD51 codon 135G〉C polymorphism and the risk of breast cancer（BC） by systematically reviewing the original studies.Methods A comprehensive search was conducted to identity all case-control studies on RAD51 codon 135G〉C polymorphism and BC risk.Meta-analysis was applied with Review Manager 5.0.24 software for calculation of pooled odds ratio（OR） value and 95%confidence interval（95%CI） of BC.Results From the 15 case-control studies selected for this meta-analysis,a total of 12 717 BC cases and 12 088 controls were included.Compared with the wild-type homozygote GG,the pooled OR（95%CI） of CC,GC,and（GC＋CC） genotypes of RAD51 codon 135G〉C for BC were 1.45（1.13,1.86）,0.95（0.75,1.20）,and 1.08（0.91,1.27）,respectively.Conclusion Homozygote CC for RAD51 codon 135G〉C polymorphism is associated with an increased risk of BC.Furthermore,heterozygote GC and（GC＋CC） for RAD51 codon 135G〉C genetic polymorphism might do not increase the risk of BC.

关 键 词：乳腺癌 乳腺肿瘤 RAD51 基因多态性 META分析 

分 类 号：R181.39[医药卫生—流行病学]