罗红霉素晶型分析及与溶解速率、溶出度的关系  

Relationship of Roxithromycin Crystal Types, Dissolution Rates and Dissolution

作　　者：王建[1,2] 曾红霞[1] 陈悦 

机构地区：[1]浙江工业大学,杭州310014 [2]浙江省食品药品检验研究院,杭州310004

出　　处：《中国现代应用药学》2013年第10期1094-1097,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：2012年国家药品评价性抽验项目

摘　　要：目的对罗红霉素的晶型进行分析,并探讨不同晶型对罗红霉素溶解速率、溶出度的影响。方法晶型分析采用X射线粉末衍射法和红外光谱法,溶解速率和溶出度测定采用转篮法,转速为100 r·min 1。结果 3种罗红霉素的结晶为3种不同的晶型,不同晶型的罗红霉素溶解速率和溶出度有一定差异。结论为罗红霉素用药的有效性提供了科学依据。OBJECTIVE To study the crystal types of roxithromycin, and the relationship of roxithromycin crystal types and its dissolution rate and dissolution. METHODS X-ray powder diffraction and infrared spectroscopy were used in the analysis of crystal types. The dissolutive apparatus was used with 100 r＇min-1. RESULTS The result showed that three crystals of roxithromycin were different crystal types, and the dissolution rates and dissolutions of different crystal types had some differences. CONCLUSION The study provids a scientific basis for the effectiveness ofroxithromycin.

关 键 词：罗红霉素 晶型 溶解速率 溶出度 X射线粉末衍射法 红外光谱法 

分 类 号：R994.11[医药卫生—毒理学]