丙泊酚的配伍研究  

Compatibility of Propofol Emulsion

作　　者：曾令全 龙万梅 傅洪[3] 魏安宁[4] 

机构地区：[1]重庆市第十三人民医院麻醉科,重庆400053 [2]重庆市第七人民医院药剂科,重庆400054 [3]重庆市中医院麻醉科,重庆400021 [4]重庆医科大学附属第二医院麻醉科,重庆400010

出　　处：《中国现代应用药学》2013年第10期1126-1131,共6页Chinese Journal of Modern Applied Pharmacy

基　　金：重庆市卫生局医学科研计划项目(2011-2-392)

摘　　要：目的考察室温下6 h内,丙泊酚乳剂与利多卡因注射液和/或地塞米松注射液配伍后的稳定性。方法采用离心分光光度法、苏丹染色实验、电导率测定以及混合液pH值和激光粒度分析等方法来考察丙泊酚(A组)、丙泊酚与利多卡因9∶1混合(B组)、丙泊酚与利多卡因4∶1混合(C组)、丙泊酚与利多卡因及0.5%地塞米松以3∶1∶1的比例混合(D组)的稳定性。结果室温下6 h内,B、C、D组与A组比较,稳定常数(Ke)值明显增高(P<0.05)。各组未见分层和颜色变化。B组与A组比较,各时点pH值明显降低,具有显著性差异(P<0.05),D组与B组比较,各时点pH值明显升高(P<0.05)。电导率值为A组<B组<C组<D组。各组丙泊酚含量均下降,下降程度各组无差异。各组在相同时点的粒径无统计学差异。结论丙泊酚与利多卡因注射液和(或)地塞米松注射液配伍后,未出现脂肪乳水解;配伍后稳定性下降,并随时间延长,进一步下降。但平均粒径未发生明显变化,说明尚可以使用,不会发生栓塞。OBJECTIVE To investigate the compatibility of propofol emulsion combined with lidocaine injection and/or dexamethasone injection. METHODS Centrifugal spectrophotometry, Sudan test, conductivity measuring, pH and laser particle size analysis were used to observe the stability of propofol（group A）, propofol and lidocaine mixed by 9 ： 1（group B）, propofol and lidocaine mixed by 4 ： 1（group C）, propofol and lidocaine and dexamethasone mixed by 3 ： 1 ： 1（group D） within 6 hours under room temperature. RESULTS The Ke of group B, C, D were significantly increased compared with group A, （P〈0.05）. Each group showed no stratification and color change. The pH of group B was decreased compared with group A at each time（P〈0.05）. The conductivity value of group A〈B〈C〈D. The content of propofol decreased in each group, but there were no differences in decend degree. The particle size had no significant difference between each group at the same time. CONCLSION When propofol combined with lidocaine injection and/or dexamethasone injection, fat hydrolysis doesn＇t occur. Stability decreases, and further down along with time. But the average particle size has no significantly changed, that showes it still can be used, no embolism will occur.

关 键 词：丙泊酚乳剂 利多卡因 地塞米松 激光粒度分析 配伍 

分 类 号：R969[医药卫生—药理学]