2012年2月-2013年2月某院50例铜绿假单胞菌和不动杆菌泛耐药、全耐药患者的治疗分析  

Analysis of 50 Cases of Pan-drug Resistance and Absolute Resistance of Pseudomonas aeruginosa and Acinetobacter in a Hospital during Feb.2012-Feb.2013

作　　者：夏勤[1] 符馨尹[2] 

机构地区：[1]南京市中医院,南京210001 [2]中国药科大学,南京211198

出　　处：《中国药房》2013年第42期3981-3983,共3页China Pharmacy

摘　　要：目的:分析某院铜绿假单胞菌和不动杆菌泛耐药、全耐药患者的抗菌药物治疗效果。方法:对2012年2月-2013年2月该院收治的50例铜绿假单胞菌和不动杆菌的泛耐药、全耐药患者的病历进行统计,回顾性分析铜绿假单胞菌和不动杆菌的特点、治疗原则及共识、耐药性、临床治疗抗菌药物的选择及治疗效果等。结果与结论:泛耐药、全耐药不动杆菌属单药治疗时头孢哌酮/舒巴坦为首选;泛耐药、全耐药铜绿假单胞菌单药治疗时以碳青霉烯类药物为首选。当有联合指征时泛耐药、全耐药不动杆菌属可选哌拉西林/他唑巴坦联合左氧氟沙星治疗;泛耐药、全耐药铜绿假单胞菌可选用头孢哌酮/舒巴坦与左氧氟沙星或依替沙星联合治疗。OBJECTIVE： To analyze medical records of pan-drug resistance and absolute resistance patients in drug sensitivity test of Pseudomonas aeruginosa and Acinetobacter, and to summarize therapeutic efficacy of antibiotics and provide guidance for clinical use of drugs. JVIETHODS： Medical records of 50 cases of pan-drug resistance and absolute resistance of P. aeruginosa and Acinetobacter were collected from a hospital during Feb. 2012- Feb. 2013. The characteristics, therapeutic principle, consensus, drug resistance, the selection of antibiotics and therapeutic efficacy of P. aeruginosa and Acinetobacter were analyzed retrospective- ly. RESULTS ＆ CONCLUSIONS： As monotherapy for pan-drag resistance and absolute resistance of Acinetobacter, cefoperazone sulbactam was preferred. As monotherapy for pan-drug resistance and absolute resistance of P. aeruginosa, carbapenems was pre- ferred. For combined indication, piperacillin/tazobactam combined with levofloxacin were suitable for pan-drug resistance and abso- lute resistance of Acinetobacter. For combined indication, cefoperazone/sulbactam combined with levofloxacin or gatifloxacin were suitable for pan-drug resistance and absolute resistance of P. aeruginosa.

关 键 词：铜绿假单胞菌 不动杆菌属 泛耐药 全耐药 治疗原则 治疗共识 

分 类 号：R969.3[医药卫生—药理学] R378[医药卫生—药学]