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出 处:《中国药房》2013年第42期3999-4001,共3页China Pharmacy
摘 要:目的:了解某院儿童药品不良反应(ADR)发生的特点及规律,促进临床合理用药。方法:采用回顾性研究方法,对该院2012年收集并上报的181例儿童ADR报告进行统计、分析。结果:181例ADR报告中,男性多于女性,〉1~3岁患儿比例最高(29.83%);ADR涉及药品种类有34种,抗感染药物占13个品种(124例,占68.51%);静脉给药引发的ADR为168例;引起皮肤及附件损害的ADR最多,有121例;严重ADR占19.89%,主要表现为过敏性休克,其中抗茵药物所致严重ADR最多(44.44%)。结论:医院应重视儿童临床用药的合理性,加强儿童药品不良反应监测,减少ADR的发生。OBJECTIVE: To study the characteristics and regularity of adverse drug reaction (ADR) in a hospital, and to pro- mote rational drug use in the clinic. METHODS: By retrospective study, 181 cases of pediatric ADR reported in the hospital in 2012 were analyzed statistically. RESULTS: Of 181 ADR cases, male case was more than female case, and the children aged over 1 to 3 years old occupied the highest proportion (29.83%); a total of 34 drug categories were involved, among which there were 13 variet- ies of antibiotics in 124 cases, accounting for 68.51% ; 168 ADR cases were induced by intravenous administration. The main clini- cal manifestations were the lesions of skin and its appendants in 121 cases. Severe ADR reports were accounted for 19.89%, mainly manifesting as allergic shock, among which antibiotics took the lead (44.44%). CONCLUSIONS: Great importance should be at- tached to rational pediatric drug use in the clinic and pediatric ADR monitoring in order to reduce the occurrence of ADR.
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