某院181例儿童药品不良反应报告分析  

Analysis of 181 Cases of Pediatric Adverse Drug Reaction in a Hospital

作　　者：左益檠[1] 毛先军[1] 

机构地区：[1]郴州市第一人民医院,湖南郴州423000

出　　处：《中国药房》2013年第42期3999-4001,共3页China Pharmacy

摘　　要：目的：了解某院儿童药品不良反应（ADR）发生的特点及规律，促进临床合理用药。方法：采用回顾性研究方法，对该院2012年收集并上报的181例儿童ADR报告进行统计、分析。结果：181例ADR报告中，男性多于女性，〉1～3岁患儿比例最高（29．83％）；ADR涉及药品种类有34种，抗感染药物占13个品种（124例，占68．51％）；静脉给药引发的ADR为168例；引起皮肤及附件损害的ADR最多，有121例；严重ADR占19．89％，主要表现为过敏性休克，其中抗茵药物所致严重ADR最多（44．44％）。结论：医院应重视儿童临床用药的合理性，加强儿童药品不良反应监测，减少ADR的发生。OBJECTIVE： To study the characteristics and regularity of adverse drug reaction （ADR） in a hospital, and to pro- mote rational drug use in the clinic. METHODS： By retrospective study, 181 cases of pediatric ADR reported in the hospital in 2012 were analyzed statistically. RESULTS： Of 181 ADR cases, male case was more than female case, and the children aged over 1 to 3 years old occupied the highest proportion （29.83%）; a total of 34 drug categories were involved, among which there were 13 variet- ies of antibiotics in 124 cases, accounting for 68.51% ; 168 ADR cases were induced by intravenous administration. The main clini- cal manifestations were the lesions of skin and its appendants in 121 cases. Severe ADR reports were accounted for 19.89%, mainly manifesting as allergic shock, among which antibiotics took the lead （44.44%）. CONCLUSIONS： Great importance should be at- tached to rational pediatric drug use in the clinic and pediatric ADR monitoring in order to reduce the occurrence of ADR.

关 键 词：药品不良反应 儿童 合理用药 

分 类 号：R969.3[医药卫生—药理学] R985[医药卫生—药学]