逆转革兰阴性耐药菌外排泵活性的研究进展  

Progress on reversal of activity of efflux pump in gram-negative resistance bacteria

作　　者：徐艳玲[1] 

机构地区：[1]南京医科大学第一附属医院呼吸内科,210029

出　　处：《国际呼吸杂志》2013年第20期1551-1555,共5页International Journal of Respiration

摘　　要：外排泵的过度表达是多重耐药菌的耐药机制之一，要对抗这种耐药机制，必须从基因、结构和功能多方面破译这个转运系统。通过了解外排泵如何工作，我们有可能发现一群新的抗菌分子，并可以统一叫做外排泵逆转剂，如膜通透性增高剂、外排泵抑制剂和外排泵竞争剂、特异性外排泵阻断剂、外排泵能量毒性剂等。目前已经发现一些化合物显示出有效阻断一些多重耐药革兰阴性菌的外排泵的作用，这一类家族代表了一个新的特异作用于细菌主动转运的抗菌素种类。Over-expression of efflux pumps is one of the mechanisms causing multidrug resistant bacteria. It is necessary to clearly decipher this transport system from the genetic, structural, and functional aspects in order to combat this poly-selective mechanism. By understanding how efflux pumps work,we may be able to find a new group of antibacterial agents, termed efflux reversals, including membrane permeabilisers, efflux pump inhibitors and flux-competitive agents, specific blockers, energy poisons,etc. Several chemical families of efflux pump inhibitors have been described and characterized. This new family of molecules represents the first antibacterial class of compound specifically targeting active transport in the bacterial cell.

关 键 词：外排泵 抑制剂 多重耐药 

分 类 号：R378[医药卫生—病原生物学]