5-氮杂-2′-脱氧胞苷在肺癌治疗中的研究进展  

h advances on 5-aza-2-deoxyeytldlne in treatment of lung cancer

作　　者：粱江水[1] 董永强[1] 殷桂林[1] 

机构地区：[1]广州军区武汉总医院心胸外科,430070

出　　处：《国际呼吸杂志》2013年第20期1578-1580,共3页International Journal of Respiration

基　　金：武汉市青年科技晨光计划（201050231090）

摘　　要：越来越多的研究认为肺癌在其发生及发展过程中表现出异常DNA甲基化模式，5-氮杂-2′-脱氧胞苷是-种DNA甲基转移酶抑制剂，能逆转肺癌DNA甲基化，从而抑制肺癌发生及发展，是目前肺癌治疗研究的新方向。尽管其研究尚处于起步阶段，但有着广阔的前景。文中就5-氮杂-2′-脱氧胞苷在肺癌治疗中的的研究进展进行综述。More and more studies suggest that the pattern of DNA methylation is abnormal in the occurrence and development of lung cancer. 5-aza-2＇-deoxycytidine which is a kind of DNA methyhransferase inhibitor can reverse the DNA methylation of lung cancer and inhibit the occurrence and development of lung cancer. This is a new field in ,the study of lung cancer treatment. Although the research is still in the initial stage, it has a broad prospect. The research advances on 5-aza-2＇- deoxycytidine in the treatment of lung cancer are reviewed briefly in this paper.

关 键 词：5-氮杂-2′-脱氧胞苷 肺癌 研究进展 

分 类 号：R979.1[医药卫生—药品]