补肾抗骨松胶囊对激素性骨质疏松作用机制的研究  

Action mechanism of kidney-tonifying and anti-osteoporosis capsules in treatment of glucocorticoid-induced osteoporosis

作　　者：伍泽鑫 罗敏[1] 陈柏陆 廖承建 洪澜[1] 

机构地区：[1]广东省惠州市中医医院,广东惠州516001

出　　处：《湖南中医杂志》2013年第10期13-14,共2页Hunan Journal of Traditional Chinese Medicine

基　　金：广东省中医药局科技项目(编号:2010066)

摘　　要：目的:探讨补肾抗骨松胶囊对激素性骨质疏松症(GIOP)的作用机制。方法:将60例GIOP患者,随机分为治疗组和对照组各30例。治疗组在原治疗的基础上加服补肾抗骨松胶囊治疗;对照组在原治疗基础上加服骨化三醇治疗。疗程均为90d。观察比较两组治疗前后血清骨保护素(OPG)、RANKL、骨碱性磷酸酶、尿I型胶原交联N端肽(NTx)水平和Ward's三角区骨密度指标变化。结果:治疗后两组血清OPG、RANKL、骨碱性磷酸酶、NTx、Ward's三角区骨密度与治疗前比较,均明显改善,差异有统计学意义(P<0.05);治疗组改善程度优于对照组(P<0.05)。结论:补肾抗骨松胶囊治疗GIOP具有一定优势,优于骨化三醇的"替代疗法",推测其机制,可能是通过OPG-RANKL-RANK骨调节轴促进骨质的形成与吸收。Objective ：To investigate the action mechanism of kidney -tonifying and anti -osteoporosis capsules in the treatment of glucocorticoid -induced osteoporosis （GIOP）. Methods：Sixty patients with GIOP were randomly divided into treatment group （n = 30 ）and control group （n = 30）. The treatment group was given kidney -tonifying and anti -osteoporosis capsules in addition to conventional treatment, while the control group was given calcitriol in addition to conventional treatment. The course of treatment was 90 d in both groups. Serum levels of osteoprotegerin （ OPG）, receptor activator of nuclear factor kappa - B ligand （ RANKL）, bone alkaline phosphatase （ BAP）, and u- rinary cross- linked N- telopeptide of type I collagen （NTx）and Ward~ triangle bone mineral density were meas- ured before and after treatment. Results：After treatment, both groups showed significant improvements in serum lev- els of OPG, RANKL, BAP, and NTx and Ward~ triangle bone mineral density （P 〈 0. 05 ） ;the treatment group had significantly more improvements than the control group （ P 〈 0. 05 ）. Conclusion ： Kidney - tonifying and anti - osteo- porosis capsules have advantages in treating GIOP and are superior to the substitutive therapy with calcitriol. They may promote the formation and absorption of bone by the OPG - RANKL - RANK system.

关 键 词：骨质疏松症 糖皮质激素性 中医药疗法 补肾抗骨松胶囊 

分 类 号：R259[医药卫生—中西医结合]