新疆缺碘地区重点人群口服碘油丸的随机化干预研究  

Study on randomized intervention of oral iodized oil among key crowd in iodine deficient areas of Xinjiang

作　　者：张玲[1] 郑蓉 王琛琛[1] 王锋锐[1] 涂杰[1] 

机构地区：[1]新疆维吾尔自治区疾病预防控制中心地方病防治科,新疆乌鲁木齐830002 [2]新疆维吾尔自治区卫生厅疾控处

出　　处：《中国地方病防治》2013年第5期346-347,350,共3页Chinese Journal of Control of Endemic Diseases

摘　　要：目的评价新疆缺碘地区重点人群（孕妇及哺乳期妇女）有针对性口服碘油丸后的干预的效果。方法利用随机对照的设计进行干预研究,以县为单位将新疆按概率比例规模抽样方法（PPS）抽取30个县随机分为干预组与对照组进行口服碘油丸干预效果的研究。排除无法参加研究的研究对象,最终参与随机干预研究的研究对象有1 020名,其中干预组为402名,对照组为618名,在给予干预组有针对性的口服碘油丸后,分析随机化干预的效果。研究对象纳入调查的标准：30个县（市）的17~50岁,怀孕3个月以内的孕妇、哺乳期妇女,且尿碘水平低于250μg/L。结果在给予干预组有针对性口服碘油丸后,干预组尿碘中位数为206.9μg/L,对照组尿碘中位数为172.2μg/L,经统计检验干预组与对照组的尿碘均数有统计学差别（Z=3.98,P=0.000 1）,干预组尿碘均数较对照组高,干预效果明显。结论随机化干预研究提示进行有针对性口服碘油丸后,可以提高孕妇及哺乳期妇女的尿碘水平,本研究可以为碘缺乏重病区实行针对性地口服碘油丸的措施提供依据。Objective According to randomized controlled design,we explored the effect of comprehensive intervention of oral iodized oil among key crowd（pregnant and lactating women） in iodine deficient areas of Xinjiang.Methods A sampling proportioned to population（PPS） survey was used in our study.The effect of intervention was carried out by dividing 30 counties randomly into intervention group and control group.Finally there were 402 women in intervention group and 618 women in control group.The intervention group were given oral iodized oil.The inclusion criteria were： age from 17 to 50,three months pregnant women and lactating women,urinary iodine levels below 250 μg / L.Results After intervention,the median urinary iodine of intervention group was 206.9 μg / L and the control group was 172.2 μg / L.Urinary iodine concentration in the intervention group were significantly improved（Z = 3.98,P = 0.0001）.Conclusion Intervention of oral iodized oil was feasible and effective to pregnant and lactating women in iodine deficient areas.The study can provide data for intervention of oral iodized oil.

关 键 词：新疆 碘缺乏 碘化油 尿碘 干预效果 

分 类 号：R591.1[医药卫生—内科学]