生化系统稳态优化的一种二次规划算法  

A quadratic programming algorithm for steady-state optimization of biochemical systems

作　　者：刘婧[1] 韩雪[1] 徐恭贤[1] 

机构地区：[1]渤海大学数理学院,辽宁锦州121013

出　　处：《渤海大学学报（自然科学版）》2013年第3期256-261,共6页Journal of Bohai University:Natural Science Edition

基　　金：国家自然科学基金(No:11101051);辽宁省高等学校优秀人才支持计划(No:LJQ2013115);辽宁省自然科学基金(No:20102003);大连理工大学海岸和近海工程国家重点实验室开放基金(No:LP1217)

摘　　要：针对一类生化系统的稳态优化问题,在已有间接优化方法(IOM)的目标函数中引入一个反映S-系统解和原模型解一致性的二次项,提出了一种改进的优化算法.该优化算法不仅得到了一致的S-系统解与IOM解,而且可用现有的二次规划算法去计算.仿真结果表明了该优化算法的实用性和有效性.A new algorithm for steady - state optimization of a class of biochemical systems is proposed in this paper. A quadratic term to account for the consistency of solutions between the S - system and original model is introduced into the existing objective function of the indirect optimization method （IOM）. The proposed opti- mization algorithm not only obtains the consistent S - system and IOM solutions, but also can be solved with a- vailable quadratic programming techniques. The simulation results show that the presented optimization algorithm is practical and effective.

关 键 词：生化系统 稳态优化 二次规划 

分 类 号：O221.2[理学—运筹学与控制论]