VEGF与WWOX蛋白在结直肠癌中的表达及其临床意义  

Expression and clinical significance of VEGF and WWOX protein in colorectal cancer

作　　者：李广鑫[1] 邓跃华[1] 刘传磊[1] 杨松海[1] 杨飞[1] 

机构地区：[1]安徽医科大学第一附属医院普外科,安徽合肥230022

出　　处：《安徽医药》2013年第10期1692-1695,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨VEGF和WWOX蛋白在结直肠癌组织及其癌旁组织中的表达、与临床病理参数的关系及两者表达的相关性。方法应用免疫组化SP法检测70例原发性结直肠癌患者术后癌组织及其癌旁组织标本中VEGF和WWOX蛋白的表达。结果结直肠癌组织中VEGF的表达率68.6%(48/70)高于癌旁组织的40%(28/70)(P<0.05),结直肠癌组织中WWOX蛋白的表达率25.7%(18/70)明显低于癌旁组织的70%(49/70)(P<0.05);VEGF与WWOX蛋白表达的高低与结直肠癌的浸润程度、分化程度、Dukes分期以及有无淋巴转移均有关(P<0.05),与患者性别、年龄、肿瘤大小等病理参数无关(P>0.05),且在结直肠癌组织中VEGF和WWOX蛋白的表达存在关联(χ2=13.961,P<0.001,r=-0.477)。结论 VEGF和WWOX蛋白在结直肠癌及癌旁组织的表达有显著差异,且VEGF和WWOX可能存在负相关关系。VEGF在结直肠癌发生及发展中发挥着至关重要的角色,联合检测VEGF和WWOX蛋白的表达对结直肠癌的早期诊断、治疗及预后具有重要的临床指导意义。Objective To investigate the expression of VEGF and WWOX protein in colorectal cancer tissue and corresponding adjacent tissue, and to discuss the correlation between VEGF, WWOX protein expressions and clinical pathological parameters. Methods The ex pressions of VEGF and WWOX protein were detected in 70 cases of primary colorectal cancer patient＇ s cancer tissue and corresponding adjacent tissue by immunohistochemical SP method. Results The expression rate of VEGF was 68.6% （48/70） in colorectal cancer tis sue, which was higher than the adjacent tissues ,40.0% （28/70） （P 〈 0.05 ） ;The expression rate of WWOX protein was 25.7% （ 18/ 70）, significantly lower than the adjacent tissues ,70.0% （49/70） （P 〈 0.05 ） ;The expressions of VEGF and WWOX protein significant ly associated with the depth of invasion, degree of differentiation, Dukes clinical stage and lymph node metastasis （ P 〈 O. 05 ）. There was no significant difference between gender, age and carcinoma size （P 〉 0.05 ）. There was negative correlation between the expression of VEGF and WWOX protein in colorectal cancer tissue （ X^2 = 13. 961,P 〈 0.001,r = - 0.447）. Conclusions The expressions of VEGF and WWOX protein in colorectal cancer tissues are significantly different. There may be a negative correlation between VEGF and WWOX protein. VEGF plays a key role in colorectal tumorigenesis and development. Joint detection of the expressions of VEGF and WWOX pro- tein in colorectal cancer has more important clinical significance in its early diagnosis, treatment and prognosis.

关 键 词：结直肠癌 VEGF WWOX蛋白 

分 类 号：R735.3[医药卫生—肿瘤]