静滴左氧氟沙星致血压升高  

Elevated blood pressure caused by intravenous drop administration of levofloxacin

作　　者：吕娟丽[1] 王楠[1] 刘振华[1] 

机构地区：[1]武警总医院药剂科,北京100039

出　　处：《中国药物应用与监测》2013年第5期300-301,共2页Chinese Journal of Drug Application and Monitoring

摘　　要：1例75岁女性患者,因细菌性肺炎、肺部阴影待查入院。给予乳酸左氧氟沙星氯化钠注射液600 mg,ivgtt,qd,输液速度1.5 mL·min-1,输液结束后,患者突然头痛、胸闷、恶心、呕吐。T 38.6℃,BP 160/80 mm Hg,神志清晰,R 20次·min-1,HR 82次·min-1,律齐。给予卡托普利片(12.5 mg,舌下含服)及硝苯地平缓释片(10 mg,qd)降压治疗,血压稍微下降,但次日再度升高。停用左氧氟沙星,换头孢米诺钠抗感染治疗,血压逐渐恢复正常。因患者抗感染效果欠佳,再次给予左氧氟沙星氯化钠注射液300 mg,ivgtt,qd,同时给予硝苯地平缓释片10 mg,bid,并监测血压,7 d后患者血压再度升高,增加降压药用量继续使用左氧氟沙星6 d,患者血压一直在高位波动。停用左氧氟沙星3 d后患者血压恢复正常,未再出现血压增高。A 75-year-old woman, hospitalized for bacterial pneumonia and pulmonary shadows with unknown origin, was administrated with intravenous drip infusion of levofloxacin-sodium chloride injection 600 mg at the infusion rate of 1.5 mL-minl once daily. The patient suddenly had headache, chest tightness, nausea and vomiting after infusion. The results of general examination showed that the body temperature was 38.6 ℃, blood pressure was 160/80 mm Hg, respiratory rate was 20 breaths per minute, and heart rate was regular with 82 beats per minute. Then captopril tablet 12.5 mg was given by sublingual administration immediately, and nifedipine sustained-release tablet 10 mg was administrated orally. The blood pressure decreased slightly, but it increased again next day. The levofloxacin injection was stopped and she recieved cefminox for anti-infective therapy, the patient＇s BP gradually returned to normal value. Due to the poor effect of anti-infection, the patient was administrated with levofloxacin injection （300 mg, ivgtt, qd）. Nifedipine sustained-release tablet （10 mg, bid） was also used for controlling blood pressure. Seven days later, the value of blood pressure rose up again. Although the double dosage of nifedipine was used, the blood pressure fluctuated in the high range during the next six days. Levofloxacin was discontinued, three days later, the patient＇s blood pressure returned to normal, after that the blood pressure did not raise again.

关 键 词：左氧氟沙星 血压升高 药品不良反应 

分 类 号：R595.3[医药卫生—内科学]