珍珠粉的食用安全性毒理学评价  

Toxicological Evaluation for the Edible Safety of Pearl Powder

作　　者：沈链链[1] 钟义红[1] 李世芬[1] 胡奇[1] 环飞[1] 王玉邦 

机构地区：[1]南京医科大学公共卫生学院,江苏省医药农药兽药安全性评价与研究中心,江苏南京210029

出　　处：《包头医学院学报》2013年第5期21-24,共4页Journal of Baotou Medical College

摘　　要：目的:对珍珠粉的食用安全性进行毒理学评价。方法:采用小鼠急性毒性试验、遗传毒性试验(Ames试验、小鼠骨髓细胞微核试验、小鼠精子畸形试验)和大鼠30 d喂养试验。结果:小鼠急性经口半数致死剂量(LD50)大于15 000 mg/(kg体重);Ames试验、小鼠骨髓细胞微核试验、小鼠精子畸形试验结果均为阴性;在30 d喂养试验中,大鼠的生长发育、血液学、生化、脏器重比及病理组织学未见与受试物相关的异常变化。结论:珍珠粉急性毒性属无毒级,无遗传毒性,珍珠粉30 d喂养实验未发现明显毒性反应,临床剂量安全。Objective： To assess the edible safety of pearl powder. Methods： The toxicity of pearl powder was investigated by acute oral tests, genetic toxicity test including Ames bacterial reverse assay, bone marrow micronucleus test in mice and mice sperm abnormality test, and 30 -day feeding tests in rats. Results： The acute oral LD50 （50 % lethal dose） in mice was over 15 000 mg/kg. No evidences of genotoxic activity to mice were found. By 30 - day feeding study, no significant changes in organ weight, hematologic and serum biochemical indices were noted, and no test substance - related pathological changes were found. Conclusion： No acute oral toxicity or genotoxicity of pearl powder was found in this study, and the toxicity of pearl powder was not observed in 30 - day feeding tests. The pearl powder is safe to be administrated in the prescribed dose.

关 键 词：珍珠粉 急性毒性 遗传毒性 30 d喂养试验 安全性评价 

分 类 号：R114[医药卫生—卫生毒理学]