Fetuin-A与2型糖尿病患者动脉粥样硬化的相关性  

Relationship between fetuin-A and atherosclerosis in type 2 diabetes mellitus

作　　者：张文洛[1] 曹悦鞍[1] 夏菁[1] 田力[1] 杨璐[1] 谢文秀[1] 彭朝胜[1] 

机构地区：[1]海军总医院特需医疗部,北京100048

出　　处：《现代医学》2013年第10期742-744,共3页Modern Medical Journal

摘　　要：目的:探讨胎球蛋白-A(fetuin-A,FA)与2型糖尿病患者动脉粥样硬化的相关性。方法:将60例糖尿病患者按颈动脉内膜中膜厚度(IMT)分为2组,糖尿病伴动脉粥样硬化组33例,IMT≥0.9 mm,或有1个以上动脉粥样硬化斑块;糖尿病不伴动脉粥样硬化组27例,IMT<0.9 mm,无动脉粥样硬化斑块。另设正常对照组(20例)。所有对象均测定FA、IMT。结果:糖尿病两组FA值较正常对照组增高,差异均有统计学意义(P<0.05);糖尿病伴动脉粥样硬化组FA值高于糖尿病不伴动脉粥样硬化组,差异有统计学意义(P<0.05)。两组FA值与IMT呈正相关。结论:FA在糖尿病动脉粥样硬化患者血清中显著升高,可作为糖尿病动脉粥样硬化的监测指标。Objective： To explore the relationship between fetuin-A and atherosclerosis in type 2 diabetes mellitus. Methods： 60 diabetic patients detected by carotid artery intima- media thickness（IMT）were divided into two groups： 33 diabetic cases with atherosclerosis group, IMT≥0.9 mm, or with more than one atherosclerotic plaque;27 diabetic cases without atherosclerosis group, IMT 〈 0.9 mm; 20 cases of normal control group. The levels of serum fetuin-A, IMT were measured in all subjects. Results： Fetuin-A values was significantly higher in diabetic group compared with the control group （ P 〈 0. 001 ）, fetuin- A values of diabetes with atherosclerosis group was higher than those of diabetes without atherosclerosis, and fetuin- A increased positively with IMT. Conclusion： Fetuin-A level in diabetic patients is significantly increased, and closely related to IMT values. Fetuin-A determination can be used as an indicator for monitoring, atherosclerosis in diabetes patients.

关 键 词：胎球蛋白-A 糖尿病 动脉粥样硬化 颈动脉内膜中膜厚度 

分 类 号：R587.1[医药卫生—内分泌] R543.5[医药卫生—内科学]