血清脂蛋白a,同型半胱氨酸与急性心肌梗死的相关性分析  

Correlation Analysis of Serum Lpa,Hcy with Acute Myocardial InfarctionLU Xiao-li1,CHENG Gong1,LI Shang-jian1,MI Peng1,ZHENG Xiao1,REN Jian-kang1,

作　　者：吕晓莉[1] 程功[2] 李尚俭[2] 弥鹏[1] 郑箫[1] 任健康[1] 陈秀生 闫福堂[1] 

机构地区：[1]陕西省人民医院检验科,西安710068 [2]陕西省人民医院心内科,西安710068 [3]西电集团医院,西安710077

出　　处：《现代检验医学杂志》2013年第5期65-67,71,共4页Journal of Modern Laboratory Medicine

基　　金：陕西省卫生厅资助项目（2012-B3）.

摘　　要：目的 探讨急性心肌梗死（AMI）患者及经皮冠状动脉介入治疗（PCI）后他汀类药对脂蛋白a（Lpa）、同型半胱氨酸（Hcy）、脂代谢指标的影响.方法 76例急性心肌梗死患者PCI术前,他汀类药治疗7天和45例健康体检者,分别测定血清Hcy,Lpa,总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）水平.结果 对照组Lpa,Hcy检测结果（132.56±41.78 mg/L,11.02±4.78 μmol/L）与AMI患者PCI术前（329.37±65.28 mg/L,27.88±19.18 μmol/L）比较差异有统计学意义（t=3.59,5.38,P均＜0.05）;PCI术前Lpa,Hcy与他汀类药治疗7天（312.15±48.4 g/L,23.70±10.1 μmol/L）比较差异无统计学意义（t=1.3,1.11,P均〉0.05）.AMI患者PCI术前与他汀类药治疗7天的TC,TG,LDL-C和HDL-C差异无统计学意义.讨论 Lpa和Hcy是AMI的危险因素,早期检测Lpa,Hcy指标有助于AMI的诊断及早期预测.Objective To study the influence of Lpa, Hcy,TC,TG,LDL-C and HDL-C in patients with acute myocardial in-farction who onundergoing percutaneous coronary intervention （PCI） and Atorvastatin. Methods Totally 76 AMI patients who underwent emergent PCI immediately before operation, 7d after operation and 45 normal group, serum Lpa, Hcy,TC, TG,LDL-C and HDL-C levels were determined. Results Lpa and Hcy level of AMI before PCI treatment group （329.37± 65.28 mg/L,27. 88±19.18 μmol/L） were significantly increased from the control group （132.56±41.78 mg/L, 11.02± 4. 78 μmol/L,t = 3.59,5.38, P〈0.05）. Compared befor PCI treatment with after PCI treatment 7d, the level Lpa and Hey showed the decreasing tendency. TC,TG, LDL-C and HDL-C were no significantly change （312.15 ± 48.4 mg/L, 23.70±10.1 μmol/L,t=1. 13,1. 11,P〉0. 05）. Conclusion Lpa and Hcy were risk factors of AMI. Detecting the serum levels of those risk factoes Lpa, Hcy as early as possible has positive value in preventing and diagnosing acute myocardial infarction.

关 键 词：脂蛋白(a) 同型半胱氨酸 经皮冠状动脉介入治疗 阿托伐他汀 急性心肌梗死 

分 类 号：R542.22[医药卫生—心血管疾病] R446.112[医药卫生—内科学]