血清同型半胱氨酸、高敏C反应蛋白的水平与阻塞性睡眠呼吸暂停低通气综合征的相关性分析  

Study of the relationship between homocysteine,high sensitive C-reactive protein and obstructive sleep apnea hypopnea syndrome

作　　者：杨秋红 刘海亮[2] 

机构地区：[1]中国建筑二局二公司医院内科,河南洛阳471001 [2]黄河三门峡医院心血管内科,河南三门峡472000

出　　处：《临床和实验医学杂志》2013年第19期1547-1549,共3页Journal of Clinical and Experimental Medicine

摘　　要：目的观察阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清同型半胱氨酸(Hcy)、高敏C反应蛋白(hs-CRP)水平,分析两者之间的相关性。方法测定54例OSAHS患者治疗前后的血清Hcy、hs-CRP水平,并与46例健康人作对照。采用荧光免疫分析法测定Hcy水平、增强免疫透射比浊法测定血清hs-CRP水平。将检测结果与睡眠呼吸监测指标进行相关性分析。结果血清Hcy、hs-CRP水平在病例组中高于对照组(P<0.01)。经呼吸机正压通气治疗后,血清Hcy、hs-CRP水平与治疗前比较明显下降,差异有统计学意义(P<0.05)。经Pearson's相关分析,OSAHS患者血浆Hcy、hs-CRP水平均与OSAHS病情的严重程度相关(P<0.05),血清hs-CRP水平与呼吸暂停低通气指数(AHI)、呼吸障碍事件最长时间呈正相关(P<0.05)。结论 Hcy、hs-CRP与OSAHS病情存在一定的相关性,动态监测Hcy、hs-CRP水平对于评价患者的疗效有一定的参考价值。Objective To evaluate the correlation of homocysteine （Hcy）, high sensitive C - reactive protein （hs - CRP） and obstructive sleep apnea hypopnea syndrome （OSAHS） by testing the level of Hcy and the hs - CRP of serum. Methods The levels of serum Hcy, hs - CRP were detected in 54 cases of OSAHS patients before and after treatment. The results of the two indexes were compared with 46 cases of healthy peo ple. The Hcy level were detected by fluorescence immunity analysis method. The hs - CRP levels were detected by the immune transmission turbidi- metric method. Test results with sleep apnea monitoring indicators were compared with correlation analysis. Results Serum Hcy, hs CRP levels in the case group is higher than those of the control group （ P 〈 0. O1 ）. After treatment with positive airway pressure breathing machine, serum Hcy, hs CRP sigrfificantly decline compared with before treatment. The difference was statistically significant （ P 〈 0.05 ）. By Pearson correlation analy sis, plasma Hcy of OSAHS patients, hs CRP levels are associated with the severity of OSAHS disease （ P 〈 0.05 ）. Serum hs CRP levels and apnea hypoventilation index （AHI） and time longest apnea events were positively correlated （ P 〈 O. 05 ）. Conclusion Hcy and hs - CRP correlated with the OSAHS. The level of Hcy and hs - CRP after therapy may have some reference value to evaluate the Treatment Effectiveness in OSAHS.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 同型半胱氨酸 高敏C反应蛋白 呼吸机正压通气治疗 

分 类 号：R56[医药卫生—呼吸系统]