新疆地区狼疮肾炎患者尿液单核细胞趋化因子1水平及临床意义  

The levels of urinary monocyte chemoattractant protein 1 and clinical significance in Xinjiang patients with lupus nephritis

作　　者：王彦焱[1] 赵春梅[1] 孟岩[1] 古丽仙.艾尔肯 张新玉[1] 贾娜[1] 罗莉[1] 

机构地区：[1]新疆医科大学第一附属医院风湿科,乌鲁木齐830054

出　　处：《新疆医科大学学报》2013年第10期1447-1450,共4页Journal of Xinjiang Medical University

基　　金：新疆维吾尔自治区自然科学基金(2013211A094)

摘　　要：目的探讨狼疮肾炎(lupus nephritis,LN)患者尿液中单核细胞趋化因子1(monocyte chemoattractant protein 1,MCP-1)的水平及其临床意义。方法采用横断面调查研究分析方法,ELISA法检测33例活动期狼疮肾炎患者和35例缓解期狼疮肾炎患者尿液中MCP-1水平。结果活动期狼疮肾炎患者MCP-1水平[468.0(205～1 990)pg/mg Cr]明显高于缓解期狼疮肾炎患者[131.5(69～734)pg/mg Cr],差异有统计学意义(P=0.000)。活动期狼疮肾炎组患者年龄(25.9±3.7)岁,缓解期狼疮肾炎组患者年龄(29.7±3.5)岁,两组年龄有统计学差异(P<0.05),活动期狼疮肾炎组患者抗ds-DNA抗体阳性率高于缓解期狼疮肾炎组患者(P<0.05)。两组在性别和族别上无统计学差异(P>0.05)。活动期狼疮肾炎组患者尿液中MCP-1水平与24h尿蛋白定量及24h尿白蛋白/肌酐(Urinary albumin-to-creatinine,UACR)呈正相关(r=0.916,P=0.000;r=0.936,P=0.000)。结论活动期狼疮肾炎患者尿液中MCP-1水平升高,对狼疮肾炎的活动性及复发具有可靠稳定的临床诊断意义。需进行前瞻性研究进一步明确其临床意义。Objective To investigate urinary levels of monocyte chemoattractant protein 1（MCP-1）in Xin-jiang patients with lupus nephritis（LN）,and analyze the relationship of MCP-1 with 24-hour proteinuria and 24-hour urinary albumin-to-creatinine ratio（UACR）in active lupus nephritis.Methods A cross-sec-tional cohort analysis was performed.Urinary MCP-1 levels of 33 active lupus nephritis patients and 35 in-active lupus nephritis were measured by ELISA.Results Urinary MCP-1 levels of active lupus nephritis patients were significantly higher than that of inactive lupus nephritis 468.0（205-1 990）pg/mg Cr vs 131.5 （69-734）pg/mg Cr,P=0.000）.The mean age of active lupus nephritis was younger than that of inactive lupus nephritis（25.9 ± 3.7 vs 29.7 ± 3.5,P 〈 0.05）and the rate of positive anti-dsDNA antibody was higher in active lupus nephritis （P 〈 0.05）.However,there was no difference in gender and ethnicity be-tween the two groups （P 〉 0.05）.Urinary MCP-1 was strongly correlated with 24-hour proteinuria and 24-hour UACR （r= 0.916,P=0.000 ;r=0.936,P=0.000）.Conclusion Urinary MCP-1 concentration is a good biomarker for the j udgment of lupus nephritis flare and activity.Providing the Longitudinal stud-ies are warranted.

关 键 词：系统性红斑狼疮 狼疮肾炎 单核细胞趋化因子 1 

分 类 号：R58[医药卫生—内分泌]