肾炎3号方对离体肾小球培养系膜细胞增殖及IL-1水平的影响  

The Effects of Shenyan No.3 on the Multiplication of Isolated Mesangial Cells and Their IL-1 Level

作　　者：姜德训[1] 黄文政[2] 杨洪涛[2] 陈志强 

机构地区：[1]北京军区总医院,北京100700 [2]天津中医学院第一附属医院,天津300192

出　　处：《北京中医药大学学报》2000年第6期33-34,共2页Journal of Beijing University of Traditional Chinese Medicine

基　　金：天津科委资助课题

摘　　要：用不同药物喂家兔后取血清加入系膜细胞培养液中观察其增殖及产生IL 1的水平。结果 :肾炎 3号方可显著抑制正常及病理状态下肾小球系膜细胞增殖及其产生IL 1的水平 ,且抑制IL 1分泌活性强于雷公藤 (P <0 0 5)。提示肾炎 3号方可抑制肾小球系膜细胞增殖及其产生IL 1水平 ,打破以系膜细胞为中心的调节网络 。In this experiment, different drugs including Shenyan No.3 (S No.3) were given to the rabbit first, and then the rabbit's serum was separated and added to into the mesangial cell culture solution; afterwards, an observation on mesangial cell multiplication and mesangial cell IL 1 level was made. The results showed that S No.3 could strikingly inhibit mesangial cell multiplication and mesangial cell IL 1 secretion under both normal and pathological conditions ( P <0 01), and the inhibiting effect of S No. 3 on mesangial cell IL 1 secretion was stronger than that of Tripterygium wilfordii ( P <0 05). The reults implies that S No.3 may have a good effect on the chronic nephritis with mesangial cell proliferation as a main evidence in its pathology.

关 键 词：肾炎3号方 肾小球系膜细胞 慢性肾炎 IL-1 

分 类 号：R285.5[医药卫生—中药学] R277.523[医药卫生—中医学]