实验性变态反应性脑脊髓炎组织病理学变化及温阳补肾方对其的影响  

Histopathological Changes in the Guinea Pigs with Experimental Allergic Encephalomyelitis and the Effects of Wenyangbushen Decoction on Them

作　　者：白丽敏[1] 宋发贤[1] 李曦[1] 李巍[1] 孙红梅[1] 李德伟[1] 许红[1] 吴海霞[1] 

机构地区：[1]北京中医药大学，北京 100029

出　　处：《北京中医药大学学报》2000年第6期35-37,共3页Journal of Beijing University of Traditional Chinese Medicine

基　　金：清华大学;香港浸会大学;北京中医药大学"中医合作研究计划"资助课题

摘　　要：在复制了实验性变态反应性脑脊髓炎 (EAE)豚鼠的基础上 ,使用HE和LuxolFastBlue染色技术 ,观察了其组织病理变化及中药复方温阳补肾方对其的影响。结果发现应用温阳补肾方可减轻EAE豚鼠的病理损害 ;海马CA - 3区的锥体细胞也参与了EAE的发病过程。The histopathological changes in the guinea pigs with experimental allergic encephalomyelitis (EAE) and the effects of Wenyangbushen Decoction (WD) on them were observed by HE and Luxol Fast Blue staining methods. The results showed that the pyramidal cells in the hippocampal CA3 area were also related to the onset of EAE, and WD could reduce the pathological lesions in the guinea pigs with EAE. The results have provided some morphologic evidence for the clinical use of WD in the treatment of multiple sclerosis.

关 键 词：多发性硬化 温阳补肾方 变态反应性脑脊髓炎 

分 类 号：R285.5[医药卫生—中药学] R277.745.1[医药卫生—中医学]