肥大细胞在慢性光损伤中的变化及研究进展  

Changes and function of mast cells in chronic photoaging

作　　者：董洪军[1] 汪晨[1] 白倩倩[1] 姚志远[1] 

机构地区：[1]卫生部中日友好医院,北京100029

出　　处：《国际皮肤性病学杂志》2013年第6期371-373,共3页International Journal of Dermatology and Venereology

摘　　要：慢性光损伤是最常见的皮肤损害，由于长期接受紫外线照射所导致。研究表明，长期曝光部位皮肤中肥大细胞的数量较非曝光部位明显增多；肥大细胞在紫外线诱导的皮肤免疫抑制中发挥一定的作用。在慢性光损伤过程中，肥大细胞通过分泌基质金属蛋白酶和类胰蛋白酶等，参与光损伤中细胞外基质及基底膜的破坏；又通过分泌细胞因子如IL-10等，限制了小鼠皮肤慢性光损伤的病理过程。Chronic photoaging is the most common form of skin damage caused by long-term uhraviolet （UV） irradiation. Studies have shown that the number of mast cells is significantly higher in sun-exposed skin than in non-sun-exposed skin, and mast cells play a certain role in UV-induced cutaneous immunosuppression. In the process of photoaging, mast cells may induce the destruction of extraeellular matrix and basement membrane by secreting matrix metalloproteinases and tryptase, and slow down the pathological process of photoaging of mouse skin by secreting eytokines such as interleukin-l0.

关 键 词：肥大细胞 光 创伤和损伤 

分 类 号：R758.1[医药卫生—皮肤病学与性病学]