羧酸化单壁碳纳米管对盐酸表柔比星吸附与释放行为的研究  

Adsorption and release behavior of epirubicin hydrochloride on carboxylated single-walled carbon nanotubes

作　　者：林锐[1] 李丽丽[2] 何佳[2] 裘兰兰[1] 何华[2,3] 

机构地区：[1]盐城卫生职业技术学院,江苏盐城224005 [2]中国药科大学分析化学教研室,江苏南京210009 [3]中国药科大学天然药物国家重点实验室,江苏南京210009

出　　处：《药学学报》2013年第11期1710-1715,共6页Acta Pharmaceutica Sinica

基　　金：中央高校科研基金资助项目(JKY2011008);盐城卫生职业技术学院青年基金资助项目(20114105);大学生创新药物研制能力提高项目(J1030830)

摘　　要：采用混酸氧化制备羧酸化单壁碳纳米管(c-SWNTs),探讨c-SWNTs对盐酸表柔比星(EPI)吸附能力与释放行为。结果表明:羧酸化修饰明显改善了单壁碳纳米管(SWNTs)的水分散性;EPI在c-SWNTs上的吸附符合准二级吸附动力学,在240 min后基本达到吸附平衡;c-SWNTs表面存在多分子层的活性作用位点,Freundlich模式比较适合用于表达EPI在c-SWNTs表面的吸附过程;碱性条件和低温条件有利于EPI在c-SWNTs表面的吸附;与多壁碳纳米管、羧酸化多壁碳纳米管及SWNTs相比,c-SWNTs对EPI的吸附能力最大。EPI在c-SWNTs的释放行为具有pH依赖性,在酸性环境中有较大的释放行为,这为其在癌细胞的靶向释放、控释研究提供了理论基础。In this study, the adsorption behavior of epirubicin hydrochloride （EPI） on carboxylated single- walled carbon nanotubes （c-SWNTs） obtained by mixture acid treatment was investigated. The results indicated that the dispersion of c-SWNTs in water was obviously improved. The absorption of EPI on c-SWNTs came to equilibrium after 240 min and could be explained by pseudo-second-order model. Moreover, there were heterogeneous distribution of active sites onto c-SWNTs surface and the Freundlich isotherm model was better fit to describe the absorption precess of EPI on c-SWNTs. The absorption capacity of EPI on c-SWNTs increased obviously with the increasing pH and decreasing temperature. Compared with multi-walled carbon nanotubes, carboxylated multi-walled carbon nanotubes, SWNTs, c-SWNTs possessed higher absorption capacity for EP1. The controlled, targeted and sustained release of EPI from c-SWNTs-EPI could be instructive for the development of nano-carrier.

关 键 词：羧酸化单壁碳纳米管 吸附 释放 盐酸表柔比星 药物转运体 

分 类 号：R943[医药卫生—药剂学]