初孕人工流产术前不同剂量米索前列醇阴道内置入的随机对照研究  

A Comparative Study on the Different Dosage of Misoprostol Administrated Intravaginally Before Surgical Abortion in Primary Pregnancy

作　　者：苏兆娟[1] 

机构地区：[1]河南省人民医院,河南郑州450003

出　　处：《实用妇产科杂志》2000年第6期300-301,共2页Journal of Practical Obstetrics and Gynecology

摘　　要：目的 :探讨人工流产术前米索前列醇阴道内置入的最佳有效剂量。方法 :将 99例早孕 (停经≤ 70天 )要求负压吸宫术终止妊娠的初孕妇女 ,按阴道内置药剂量的不同 ,随机分为 3组 :2 0 0μg组 35例 ,40 0μg组 32例及 6 0 0μg组32例 ,分别于施术前 3h阴道后穹窿置米索前列醇 2 0 0 μg、40 0 μg及 6 0 0 μg,观察各组有效宫颈扩张度 (≥ 7.0 mm)比率、术中出血情况及用药后副反应发生率。结果 :三组有效宫颈扩张度比率 ,以 40 0 μg组 93.75 % (30 / 32 )及 6 0 0 μg组 96 .88% (31/ 32 )显著高于 2 0 0μg组 34.2 9% (12 / 35 ) (P<0 .0 0 5 ) ,其中 40 0μg与 6 0 0μg组相比 ,差异无显著性 (P>0 .0 5 ) ,三组中术中出血量 2 0 0 μg组 18.6 7± 3.2 4ml,40 0 μg组 16 .38± 3.5 2 ml及 6 0 0 μg组 17.6 0± 2 .73ml,各组间差异均无显著性 (P>0 .0 5 ) ,用药后副反应发生率 ,以 6 0 0 μg组 15 .6 3% (5 / 32 )显著高于 40 0 μg组 3.15 % (1/ 32 )。结论 :40 0 μg米索前列醇阴道内置入可作为人工流产术前扩张宫颈的最佳有效剂量和理想的给药途径。Objective: To determine the best dosage of Misoprostol administrated intravaginally on the effect of cervical dilatation before surgical abortion.Method:[WT5”BZ]ninty nine women with early pregnancy were divided randomlly into three groups:Group 200 μg (35 cases),Group 400 μg(32 cases)and Group 600 μg(32 cases)according to the different dosage of Misoprostol administrated intravaginally before surgical abortion.They were given 200 μg,400 μg and 600 μg Misoprostol administrated intravaginally 3 hours before operation respectively.The rate of the effective cervical dilatation(≥7.0mm),the amount of the vaginal bleeding during the operation and the side effects of Misoprostol were observed.Results:[WT5”BZ]The rate of the effective cervical dilatation were 34.29%(12/35) in Group 200 μg,93.75%(30/32) in Group 400 μg and 96.88% (31/32)in Group 600 μg,respectively.Among them the rate of effective cervical dilatation in the later two groups were significantly higher than that of the former one( P <0.005),while there was no significant difference between the later two groups.The amount of vaginal bleeding were 18.67±3.24 ml,16.38±3.52 ml and 17.60±2.73 ml,respectively.There was no significant diffrence among them.The rate of the side effects of Misoprostol in Group 600 μg(15.13%,5/32)were higher significantly than that of Group 400 μg(3.15%,1/32)( P <0.05).Conclusion:400 μg Misoprostol administrated intravaginally is the best dosage on the effect of the cervical extension before surgical abortion.

关 键 词：米索前列醇 早期妊娠 人工流产 阴道内置入 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]