布托啡诺配伍异丙酚用于无痛可视人工流产术的临床评价  

Butorphanol plus propofol for analgesia in painless visible artificial abortion

作　　者：庄越[1] 金文香[2] 杨贺飞[1] 

机构地区：[1]广州开发区医院麻醉科,510730 [2]广州医学院第二附属医院麻醉科

出　　处：《中华生物医学工程杂志》2013年第3期246-248,共3页Chinese Journal of Biomedical Engineering

摘　　要：目的探讨布托啡诺配伍异丙酚用于无痛可视人工流产术的效果及安全可行性。方法2011年5月本院妇科门诊自愿实施无痛人工流产术患者120例完全随机分2组，布托啡诺组和芬太尼组各60例。于麻醉诱导前5min，布托啡诺组静脉注射布托啡诺0．02mg／kg；芬太尼组注射芬太尼0．001mg／kg，然后异丙酚麻醉诱导，术中以微量泵持续追加或维持，比较两组疗效及不良反应发生情况。结果布托啡诺组止痛效果与芬太尼组比较差异无统计学意义（P〉O．05）。布托啡诺组异丙酚使用总量低于芬太尼组[（139．0±12，0）比（170．0±18．5）mg，P〈O．05]；对呼吸的抑制作用较轻（P〈O．05）；呛咳反应发生率明显低于芬太尼组（P〈0．叭）；术后苏醒时间明显短于芬太尼组（P〈O．05）；且无一例不良反应和并发症发生。结论与传统方法相比，布托啡诺伍用异丙酚用于无痛可视人工流产术效果好，未见不良反应。Objective To study the efficacy and safety of butorphanol plus propofol for anesthesia in painless visible artificial abortion. Methods In May 2011, 120 pregnant women who voluntarily received painless artificial abortion in our department were randomly assigned to be treated with 0.02 mg/kg butorphanol （butorphanol group, n=60） and fentanyl （fentanyl group, n=60） at 5 min prior to induced anesthesia using propofol, which were then supplemented via venous pumps during the surgery for maintenance anesthesia. The efficacy and adverse reactions were compared. Results The difference in analgesic effect was unremarkable between both groups （P〉0.05）. Compared with fentanyl for anesthesia, a reduced dose was noted for butorphanol [ （139.0± 12.0） vs （170.0± 18.5） mg, P〈0.05] , thus resulting in minor respiratory inhibition and markedly reduced incidence of bucking （all P〈0.05 ）. Patients treated with butorphanol yielded a shorter duration to recovery of consciousness compared with those receiving fentanyl （P〈0.05）. No adverse reaction or complication was documented. Conclusion Butorphanol plus propofol has better efficacy of anesthesia in painless visible artificial abortion without adverse reactions.

关 键 词：布托啡诺 芬太尼 异丙酚 流产 人工 呼吸功能不全 

分 类 号：R614[医药卫生—麻醉学]