育龄妇女ToRCH感染及与异常妊娠关系的研究  

A Study on the Relationship Between ToRCH Infection in Women of Childbearing Age and Abnormal Pregnant Outcome

作　　者：史百芬[1] 黄升海[1] 王明丽[1] 李京培[1] 孟蔚春[2] 胡勇[1] 

机构地区：[1]安徽医科大学,安徽合肥230032 [2]合肥市妇幼保健院,安徽合肥230001

出　　处：《实用妇产科杂志》2000年第6期316-317,共2页Journal of Practical Obstetrics and Gynecology

摘　　要：目的 :研究育龄妇女 To RCH系列感染及其与异常妊娠结局的关系。方法 :采用间接 EL ISA对 2 5 0例育龄妇女作 4种 To RCH病原体抗体检测 ,部分 Ig M(或 Ig G)阳性病例并作 PCR检测。对其中 2 1例异常妊娠结局的胚胎组织块作了 PCR检测和对 10例异常新生儿作了血清学诊断。结果 :2 5 0例育龄妇女 To X、Rub V、CMV、HSVIg M阳性率分别为 8.0 %、12 .8%、6 .8%和 8.4% ,并发现同一病例有两种或两种以上病原体同时感染的情况 ,PCR结果与之基本一致。2 1例与 To RCH感染有关异常妊娠结局 (流产、早产、死胎、先天缺陷 )孕妇均有 To RCH中的一种、2种或 2种以上病原体感染 ,从死胎脑组织块、人工流产混合物的 PCR结果与之吻合。 10例新生儿脑炎血清与对应母亲血清抗体检测表明 ,垂直传播率 To X与 CMV分别为 5 0 %和 40 %。结论 :To RCH系列感染与异常妊娠结局的关系十分密切。Objectives:To study the relationship between a series of ToRCH infection in women of childbearing age and abnormal pregnant outcome.Methods:The sera from 250 women of childbearing age were tested for anti-4 pathogens of ToRCH antibodies with an indirect ELISA,and a part of IgM(or IgG)positive cases are detected by PCR assay again.Parts of embryo tissues from 21 women of abnormal pregnant outcome are detected by PCR,and the sera from to abnormal newborns are detected by ELISA.Results:The positive rates of Anti ToX,RubV,CMV and HSV-IgM are 8.0%,12.8%,6.8% and 8.4% respectively,there are two or beyond two of pathogens infection simultaneously in the same case,the result of PCR is similar to ELISA′s 21 abnormal pregnant women that associated with ToRCH infection have one,two or beyond two of ToRCH infection,similar to PCR′s for 4 still birth′brain tissues and 6 miscarriages′ mixtures.The antibodies of 10 encephalitis of newborns and their mothers suggest that the vertical spread rates of ToX and CMV are 50% and 40% respectively.Conclusions:The relationship between a series of ToRCH infection and abnormal pregnant outcome is very close.

关 键 词：孕妇 TORCH感染 异常妊娠结局 育龄妇女 

分 类 号：R714.251[医药卫生—妇产科学] R512.99[医药卫生—临床医学]