EBV、Hp感染与胃癌的关系及相互作用研究  

Correlation Analysis between EBV and Hp Infection and Gastric Cancer

作　　者：杨艳丽[1] 胡建国[2] 司岑[2] 

机构地区：[1]宁夏医科大学研究生学院,750004 [2]宁夏医科大学总医院消化科

出　　处：《天津医药》2013年第11期1048-1051,共4页Tianjin Medical Journal

基　　金：宁夏自然科学基金资助项目(项目编号:NZ08101)

摘　　要：目的探讨Epstein-Barr virus(EBV)、幽门螺旋杆菌(Hp)感染与胃癌发生的关系及二者的相互作用。方法采用聚合酶链反应(PCR)和原位杂交(ISH)技术检测100例胃癌组织(胃癌组)及82例胃炎组织(胃炎组)中EBV的感染情况,采用PCR技术检测Hp感染情况,分析EBV、Hp感染与胃癌患者临床病理特征的关系及二者的相关性。结果胃癌组EBV和Hp的感染阳性率均高于胃炎组(9.0%vs 0和56.0%vs 40.2%,均P<0.05)。贲门胃体癌较胃窦癌EBV感染率高(16.3%vs 2.0%,P<0.05),低分化癌较中高分化癌EBV、Hp感染率高(15.7%vs 2.0%和66.7%vs44.9%,均P<0.05),不同性别、年龄、民族及有无淋巴结转移间EBV、Hp感染率差异无统计学意义,不同发生部位间的Hp感染率差异无统计学意义。胃癌组EBV与Hp感染无相关性(r=0.137,P>0.05)。结论 EBV、Hp感染是胃癌发生的2个独立因素,二者均与胃癌的恶性演进有关。Objective To investigate the correlation between Epstein-Barrvirus （EBV） and H.pylori （Hp） infection and gastric cancer. Methods The EBV infection was examined by polymerase chain reaction （PCR） and in situ hybridiza- tion （ISH） in 100 samples of gastric cancer tissue and 82 samples of gastritis tissue. The Hp infection was detected by PCR. The correlation between EBV and Hp infection and clinical and pathological features was analyzed in patients with gastric cancer. Results The positive rates of EBV and Hp were significantly higher in gastric cancer tissues than those in gastritis tissues （9.0% vs 0 and 56.0% vs 40.2%, P 〈 0.05）. There was significantly higher infection rate in EBV in cardia gastric can- cer than that of gastric cancer （16.3% vs 2.0%, P 〈 0.05）. There were significantly higher infection rates in EBV and Hp in poorly differentiated carcinoma than those of well-differentiated carcinoma （15.7% vs 2.0% and 66.7% vs 44.9%, P 〈 0.05）. There were no significant differences in EBV and Hp infection between gender, age, nationality and lymph node metastasis （P 〉 0.05）. There was no significant difference in Hp infection between different parts of gastric cancer. There was no correla- tion between EBV and Hp infection in gastric cancer tissues （r=0.137, P 〉 0.05）. Conclusion EBV and Hp infection are two independent factors in the development of gastric cancer, and both of them are associated with the malignant evolution of gastric cancer.

关 键 词：螺杆菌 幽门 疱疹病毒4型 人 胃肿瘤 癌 螺杆菌感染 爱泼斯坦巴尔病毒感染 

分 类 号：R259.733[医药卫生—中西医结合]