A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity  

作　　者：Tong Guo Yi Lu Peixue Li Meng-Xin Yin Dekang Lv Wenjing Zhang Huizhen Wang Zhaocai Zhou Hongbin Ji Yun Zhao Lei Zhang 

机构地区：[1]State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China

出　　处：《Cell Research》2013年第10期1201-1214,共14页细胞研究（英文版）

摘　　要：The Hippo （Hpo） pathway controls tissue growth and organ size by regulating the activity of transcriptional co-ac- tivator Yorkie （Yki）, which associates with transcription factor Scalloped （Sd） in the nucleus to promote downstream target gene expression. Here we identify a novel protein Sd-Binding-Protein （SdBP）/Tgi, which directly competes with Yki for binding to Sd through its TDU domains and inhibits the Sd-Yki transcriptional activity. We also find that SdBP retains Yki in the nucleus through the association with Yki WW domains via its PPXY motifs. Collectively, we identify SdBP as a novel component of the Hpo pathway, negatively regulating the transcriptional activity of Sd- Yki to restrict tissue growth.The Hippo （Hpo） pathway controls tissue growth and organ size by regulating the activity of transcriptional co-ac- tivator Yorkie （Yki）, which associates with transcription factor Scalloped （Sd） in the nucleus to promote downstream target gene expression. Here we identify a novel protein Sd-Binding-Protein （SdBP）/Tgi, which directly competes with Yki for binding to Sd through its TDU domains and inhibits the Sd-Yki transcriptional activity. We also find that SdBP retains Yki in the nucleus through the association with Yki WW domains via its PPXY motifs. Collectively, we identify SdBP as a novel component of the Hpo pathway, negatively regulating the transcriptional activity of Sd- Yki to restrict tissue growth.

关 键 词：HIPPO SD 

分 类 号：Q959.842[生物学—动物学] O123[理学—数学]