Coordinated regulation of AMPK activity by multiple elements in the a-subunit  

作　　者：Feng-Jiao Xin Jue Wang Rong-Qing Zhao Zhi-Xin Wang Jia-Wei Wu 

机构地区：[1]MOE Key Laboratory of Protein Science and Tsinghua-Peking Centerfor Life Sciences, School of Life Sciences, Tsinghua University, Beijing100084, China

出　　处：《Cell Research》2013年第10期1237-1240,共4页细胞研究（英文版）

基　　金：Acknowledgments This work was supported by the National Natural Science Foundation of China （31130062）, the National Key Basic Research Program of China （2013CB530603） and Tsinghua University （20121080028）.

摘　　要：The AMP-activated protein kinase （AMPK） is the key energy sensor in response to various stresses that decrease cellular ATP levels, including low glucose, hy- poxia, ischemia and heat shock. Recently, evidence has suggested that AMPK also plays critical roles in coupling the cellular bio-energetic state to various physiological processes, such as tumor suppression, cell polarity, life span, circadian clock, gene transcription and autophagy. Thus, AMPK represents a potential drug target for meta- bolic disorders and cancer treatment [1, 2].

关 键 词：AMPK 元素 亚基 调控 活性 生物能量 ATP水平 AMP激活 

分 类 号：Q616[生物学—生物物理学] S831.1[农业科学—畜牧学]