外周血CD4^+CD25^+ Treg细胞与HBV携带者相关性的Meta分析  

Correlation between peripheral blood CD4^+CD25^+ Treg cells and disease progression and prognosis in HBV carriers:A Meta-analysis

作　　者：潘宗琴[1] 吕红[1] 胡世芸[1] 陈宇[1] 庄勤建[1] 徐林[2] 姚新生[2] 肖政[3] 邱隆敏[1] 

机构地区：[1]遵义医学院附属医院感染科,贵州省遵义市563000 [2]遵义医学院免疫学教研室,贵州省遵义市563000 [3]遵义医学院循证医学中心(循证医学教育部网上合作研究中心遵义医学院分中心),贵州省遵义市563000

出　　处：《世界华人消化杂志》2013年第29期3124-3131,共8页World Chinese Journal of Digestology

基　　金：贵州省优秀科技教育人才省长专项基金资助项目;No.黔省专合字(2008)111号;贵州省社会发展公关基金资助项目;No.黔科合SY[2010]3049号~~

摘　　要：目的:探讨CD4+CD25+Treg细胞在乙型肝炎病毒(hepatitis B virus,HBV)携带者及相关感染状态中分布特征,以期揭示其与HBV携带者的相关性,为临床干预提供依据.方法:计算机检索Pubmed、SCI、Embase、CNKI、万方及维普等数据库,依据NewcastleOttawa Scale(NOS)标准评价文献质量,按照PICOS原则提取资料,采用RevMan5.1软件进行Meta分析.结果:纳入文献24篇.HBV携带者外周血Treg细胞含量较健康对照高(P=0.01);与HBV携带者比较,慢性乙型肝炎Treg细胞含量较高(P=0.12),急性乙型肝炎较低(P=0.15);慢性HBV携带者Treg细胞高于非活动性HBsAg携带者(P=0.01).Treg细胞含量与HBV DNA、丙氨酸转氨酶是否存在相关性,因研究一致性差,结论尚不能确定.结论:CD4+CD25+Treg细胞可能成为影响HBV携带者预后及转归的重要因素.AIM： To reveal the relationship between peripheral blood CD4^＋CD25^＋ Treg cells and disease progression and prognosis in HBV carriers by investigating the distribution characteristics of peripheral blood CD4^＋CD25^＋ Tregs in HBV carriers and other patients with HBV infection. METHODS： Two reviewers independently searched relevant articles in the databases （PubMed, SCI, Embase, CNKI, WanFang and VIP）, evaluated their quality, extracted data and synthesized the data by meta-analysis. RESULTS： Twenty-four case-control studies were included, but their quality was not high. The level of CD4^＋CD25^＋ Tregs was significantly higher in HBV carriers than in healthy controls （P = 0.01）. Compared with HBV carriers, a significantly higher level of CD4^＋CD25^＋ Tregs was observed in CHB patients （P = 0.12）, but a significantly lower level of these cells was noted in patients with acute hepatitis B （P = 0.15）. The level of CD4^＋CD25^＋ Tregs in chronic HBV carriers was higher than in inactive HBsAg carriers （P = 0.01）. CONCLUSION： CD4^＋CD25^＋ Treg cells may play an important role in disease progression and prognosis in HBV carriers.

关 键 词：HBV携带者 CD4^+CD25^+TREG细胞 调节性T细胞 META分析 

分 类 号：R512.62[医药卫生—内科学]