老年陈旧性心肌梗死患者心肌细胞成形术早期预后的分子标志物研究  

Molecular markers for early prognosis of cellular cardiomyoplasty in elderly patients with old myocardial infarction

作　　者：李侠[1] 郭燕[1] 胡有东[1] 陈颖[1] 郭殿选[1] 周华兰[1] 杨海晨[1] 李霞[1] 

机构地区：[1]徐州医学院附属淮安医院老年病科,淮安市223002

出　　处：《中华老年医学杂志》2013年第11期1155-1158,共4页Chinese Journal of Geriatrics

基　　金：基金项目：江苏省高校自然科学研究计划项目（KJD310234）;江苏省淮安市科技局科技项目（HAS04020）;江苏省淮安市科技支撑计划项目（HAS2011020）

摘　　要：目的探讨CDl33＋、CDl4＋CDl6＋和CD42b表达水平与老年陈旧性心肌梗死患者心肌细胞成形术早期预后的相关性。方法采用流式细胞仪检测经皮冠状动脉介入治疗（PCI）＋支架植入术患者和PCI＋支架植入术＋人脐带造血干细胞（hUCM）移植术患者循环CDl33＋、CDl4＋CDl6＋和CD42b的表达水平与心肌梗死面积和左心室射血分数（LVEF）的关系。评估CDl33＋、CDl4＋CDl6＋和CD42b对细胞心肌成形术早期预后的影响。结果PCI＋支架植入术后8周CDl33＋（O．05±0．02）％、CDl4＋CDl6＋（O．9±0．2）％、CD42b（70．6士1．3）％，PCI＋支架植入术＋hUCB移植后8周CDl33＋（0．07士0．01）％、CDl4＋CDl6＋（0．6士0．3）％、CD42b（80．2土8．3）％，两组比较，差异有统计学意义（P〈O．01）。结论CDl33＋、CDl4＋CDl6＋和CD42b表达水平可能预测老年陈旧性心肌梗死患者心肌细胞成形术的早期预后。Objective To study the relationship between expression of peripheral blood CD133＋, CD14 ＋CD16＋, CD42b and early prognosis of cellular cardiomyoplasty in elderly patients with old myocardial infarction. Methods The expressions of circulating CD133＋ ,CD14＋CD16＋ ,CD42h in elderly patients with coronary stent implantation and cellular cardiomyoplasty were measured by flow cytometry to observe the effects of levels in CD133-k ,CD14-kCD16＋ and CD42b on infarct size and left ventricular ejection fraction （LVEF）. Results At eight weeks, there were significant difference in molecular markers between cellular cardiomyoplasty and coronary stent implantation CD133 ＋ （0.07±0.01）%,CDI4＋CDI6＋（0.6±0.3）,CD42h（80.2±8.3）% vs. CDI33＋（0.05±0.02）, CD14-kCD16-k（0.9±0.2）% ,CD42b（70.6±1.3） all P〈0.01. Conclusions The changes of CD133＋,CD14＋CD16＋, CD42b may predict early prognosis of cellular cardiomyoplasty in elderly patients with old myocardial infarction.

关 键 词：心肌梗死 肌细胞 心脏 血管成形术 经腔 经皮冠状动脉 

分 类 号：R542.22[医药卫生—心血管疾病]