亚甲基四氢叶酸还原酶基因C677T多态性与中国人群糖尿病肾病相关性的Meta分析  

Association between methylenetetrahydrofolate reductase gene C677T polymorphism and diabetic kidney disease in Chinese population： a meta-analysis

作　　者：孙亮[1] 王松岚[2] 史晓红[1] 杨泽[1] 

机构地区：[1]卫生部北京医院卫生部老年医学研究所卫生部老年医学重点实验室,100730 [2]卫生部北京医院肾脏内科

出　　处：《中华老年医学杂志》2013年第11期1255-1258,共4页Chinese Journal of Geriatrics

基　　金：北京市科技新星计划（Z121107002512058）;国家自然科学基金（30972709,81061120527）;卫生部部管医院临床学科重点项目（10120101）

摘　　要：目的评价中国人群糖尿病肾病与亚甲基四氢叶酸还原酶（MTHFR）基因c677T多态性的相关性。方法根据系统评估的原理和规范，检索外文专业期刊数据库（PubMed、Medline、EMBAsE）及中文期刊数据库，分别基于隐性遗传模型和显性遗传模型，meta分析评估MTHFR基因C677T位点风险等位基因T与中国人群糖尿病肾病的相关性。异质性检验后采用M—H固定效应模型合并比值比（0l尺）值，采用Begg和Egger偏倚分析评估本项meta分析的发表偏倚。结果共纳入10篇文献，包含共计2018例人群数据结果。异质性检验表明不存在异质性，选择M—H固定效应模型进行数据合并，隐性模型合并后的OR为2．41（95％CI=1．85～3．13），显性模型合并后的OR为2．33（95％CI=1．82～2．98）。Begg和Egger偏倚分析显示隐性和显性遗传模型下都无明显发表偏倚。结论MTHFR基因C677T位点风险等位基因T与中国人群糖尿病肾病的发生风险正相关。Objective To evaluate the association between methylenetetrahydrofolate reductase gene （MTHFR） C677T polymorphism and diabetic kidney disease in Chinese population. Methods After searching the related literatures from PubMed, Medline, EMBASE databases and common Chinese journal literature databases, meta-analysis was performed to assess the association of MTHFR C677T polymorphism with diabetic kidney disease according to the principles of systematic review based on the recessive model and dominant model respectively. Fixed effect model （M-H） was used to pool odd ratio （OR） after heterogeneity test. The Begg and Egger analysis were conducted to evaluate the publication bias. Results 10 literatures including a total of 2018 cases were included in the meta analysis. No significant heterogeneity was detected. Data were pooled by fixed effect model. The total OR was 2.41 （95%CI= 1.85-3.13） and 2.33 （95MCI= 1.82-2.98） in recessive and dominant models respectively. No obvious publication bias was observed by Begg and Egger analysis. Conclusions The T allele of C677T polymorphism in MTHFR gene is positively associated with diabetic kidney disease in Chinese Dooulation.

关 键 词：糖尿病肾病 亚甲基四氢叶酸还原酶 基因组结构变异 META分析 

分 类 号：R587.2[医药卫生—内分泌] R692[医药卫生—内科学]