Fluorescence triggered by ligand-protein hydrophobic interaction  

作　　者：LIU ZhenZhen DU LuPei LI MinYong 

机构地区：[1]Department of Medicinal Chemistry,School of Pharmacy,Shandong University

出　　处：《Science China Chemistry》2013年第11期1667-1670,共4页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China (81370085);the Program of New Century Excellent Talents in University (NCET-11-0306);the Fok Ying Tong Education Foundation (122036);the Shandong Natural Science Foundation (JQ201019);the Independent Innovation Foundation of Shandong University (2010JQ005 and 2012JC002).

摘　　要：Hydrophobic fluorescence:Tan and his colleagues recently introduced a brand new chemotype of environment-sensitive fluorescent turn-on probes to detect the hydrophobic ligand-binding domain by using SBD fluorophore.The design strategy described in this report generalized the environment sensitivity turn-on mechanism to recognize a specific protein,which provides a robust breakthrough for interchanging fluorescence in conventional small-molecule fluorescent imaging.Hydrophobic fluorescence： Tan and his colleagues recently introduced a brand new chemotype of environment-sensitive fluorescent turn-on probes to detect the hydrophobic ligand-binding domain by using SBD fluorophore. The design strategy described in this report generalized the environment sensitivity turn-on mechanism to recognize a specific protein, which provides a robust breakthrough for interchanging fluorescence in conventional small-molecule fluorescent imaging.

关 键 词：non-enzyme protein environment-sensitive probe turn-on fluorescence SBD fluorophore 

分 类 号：O657.3[理学—分析化学]