糖尿病与良性前列腺增生的相关性研究  

Correlation between Diabetes and Benign Prostatic Hyperplasia

作　　者：孟宪琴[1] 刘伟[1] 屈晓冰[2] 杜万红[1] 刘颖[2] 

机构地区：[1]中国人民解放军第163医院老年病科,湖南省长沙市410003 [2]中南大学湘雅二医院老年病科

出　　处：《中国全科医学》2013年第30期3547-3550,共4页Chinese General Practice

基　　金：中央保健委员会基金(B2009A058);湖南省科技厅资助项目(2009FJ3076);长沙市科技项目计划(K0902169-31)

摘　　要：目的探讨糖尿病与良性前列腺增生(BPH)的相关性。方法选择2008年2月在中南大学湘雅二医院和2009年3月在中国人民解放军第163医院老年病科门诊就诊的BPH患者为调查对象。应用BPH与糖尿病相关性研究调查表和国际前列腺症状评分表(IPSS)对其进行调查并通过分组分析糖尿病与BPH患者前列腺增生指标的关系。结果 (1)调查期间有131例就诊的老年BPH患者愿意接受进一步调查,最终入选者117例。(2)与单纯BPH组相比,BPH合并糖尿病组的前列腺体积(PV)和血清前列腺特异性抗原(PSA)值均升高,且差异有统计学意义(P<0.05)。(3)空腹血糖(FBG)升高组患者的PV和PSA值较正常组高,差异有统计学意义(P<0.05)。糖化血红蛋白(HbA1c)异常组的PV较正常组高,差异有统计学意义(P<0.05)。高胰岛素血症(HINS)组较空腹胰岛素(FINS)正常组,胰岛素抵抗组较敏感组的PV值高、病程长,差异均有统计学意义(P<0.05)。(4)以BPH进展性为因变量,以FBG、餐后2 h血糖(2 hPBG)、HbA1c、FINS、胰岛素抵抗指数(HOMA-IR)为自变量,进行Logistic逐步回归分析,结果显示,FBG、FINS进入回归方程。结论糖尿病可促使BPH患者PV的增长和病程的延长,FBG和FINS更是其进展性的危险因素,临床医生应加以关注。Objective To explore the correlation between diabetes mellitus （DM） and benign prostatic hyperplasia （BPH）. Methods The subjects consisted of 117 outpatients with BPH treated in Geriatrics departments in Central South University Xiangya Second Hospital in February 2008 and in 163 Hospital of PLA in March 2009. The information on DM, BPH and vital signs were collected with the questionnaire on BPH associated with DM, the International Prostate Symptom Score （IPSS）, and physical examinations. After grouping the outpatients, we analyzed the relationships between DM and BPH. Results Compared with the BPH group, BPH with DM group also had significantly higher levels of prostate volume （PV） and serum prostate specific antigen （PSA） level （ P 〈 0. 05 ）. The levels of PV and PSA in the group with elevated FBG ievel were significantly higher than those in the normal FBG group （ P 〈 0. 05 ）. Compared with the group with abnormal HbAlo, the group with normal HbAlo had a significantly higher value of PV （ P 〈 0.05 ）. BPH patients with NINS and insulin resistance had a larger prostate and a longer course of the disease than BPH patients with normal FINS and insulin sensitivity （ P 〈 O. 05 ）. Taking the progression of BPH as the dependent variable, FBG, 2 hPBG, HbAlo, FINS, HOMA -IR as independent variables, the Logistic regression analysis showed that FBG and FINS entered the equation. Conclusion Diabetes can promote the growth of PV and ex- tend the course of BPH, and FBG and FINS are the risk factors of the progression of BPH, which the clinicians must watch out for.

关 键 词：糖尿病 前列腺增生 问卷调查 

分 类 号：R697.3[医药卫生—泌尿科学]