P-糖蛋白与CYP450酶对千金子肠道毒性的影响  

P-glycoprotein and cytochrome CYP450 enzymes affect the intestinal toxicity of Euphorbia lathyris

作　　者：段飞鹏[1] 王英姿[1] 倪健[1] 张超[2] 孙秀梅[2] 冯艾灵[1] 

机构地区：[1]北京中医药大学,北京100102 [2]山东中医药大学,山东济南250355

出　　处：《药学研究》2013年第10期593-595,共3页Journal of Pharmaceutical Research

基　　金：国家自然科学基金(No.81274082);北京市自然科学基金(No.7122093);北京市优秀人才项目(No.2012D009999000002)

摘　　要：P-糖蛋白和细胞色素CYP450酶为体内重要的转运蛋白和代谢酶,参与药物在体内的吸收和代谢。千金子对胃肠道有强烈的刺激作用,可以产生峻泻,本文将从P-糖蛋白和CYP450酶功能着手分析二者对千金子肠道毒性的影响,为千金子肠道毒性的研究提供新的思路和方法。P- glycoprotein and cytochrome CYP450 enzymes are important transporters and metabolic enzymes in the body, and their play an important role in absorption and metabolism of drugs. Euphorbia lathyris has strong stimulation to the gastrointestinal tract j can induce seriously diarrhea. This article focused on the functions of P - glycoprotein and cytochrome CYP450 enzymes to analyze the reason why Euphorbia lathyris could lead to intestinal toxicity, and provided a new idea and method to reseai＇ch the intestinal toxicity of Euphorbia lathyris.

关 键 词：P-糖蛋白 CYP450酶 千金子 肠道毒性 

分 类 号：R285[医药卫生—中药学]