伊曲康唑胶囊联合2％酮康唑乳膏治疗足癣的近期临床疗效观察  

To observe the efficacy of oral Itraconazole Capsules combined with external use 2% ketoconazole cream treating tinea pedis

作　　者：谢顺珍[1] 邓列华[1] 胡云峰[1] 赵刚[1] 刘赛君[1] 孙乐栋[2] 罗育武[3] 李克俭[1] 徐瑾[1] 李诗娜[1] 陈国瑞[1] 

机构地区：[1]暨南大学附属第一医院皮肤科,广东广州510630 [2]南方医科大学珠江医院皮肤科,广东广州510280 [3]广州市皮肤病防治所,广东广州510095

出　　处：《医学美学美容（中旬刊）》2013年第9期15-17,共3页

摘　　要：目的：观察伊曲康唑胶囊联合2％酮康唑乳膏治疗足癣的近期临床疗效。方法：将94例足癣患者随机分为治疗组（口服伊曲康唑胶囊200mg每天1次，联合外用2％酮康唑乳膏每天2次）；对照组（单纯外用2％酮康唑乳膏每天2次）；两组各47例，用药疗程均为4周。观察两组患者用药后2周、4周及停药后2周的临床疗效和真菌学疗效及不良反应。结果：用药后2周治疗组和对照组总有效率分别为25．5％、17．o％，真菌清除率分别为25．5％、17．o％，两组比较差异无统计学意义（P〉0．05）；用药后4周治疗组和对照组总有效率分别为61．7％、40．4％，真菌清除率分别为68．1％、44．7％，两组比较差异有统计学意义（P〈0．05）；停药后2周治疗组和对照组总有效率分别为80．9、55．3％，真菌清除率分别为89．4％、59．6％，两组比较差异有统计学意义（P〈0．05）。两组患者用药后均无严重不良反应发生。结论：口服伊曲康唑胶囊联合外用2％酮康唑乳膏比单纯外用2％酮康唑乳膏治疗足癣近期临床疗效及真菌学疗效好，且副作用少，是临床治疗足癣疗效较好的方法之一。Objective： To observe the efficacy of oral Itraconazole Capsules combined with external use 2 % ketoconazole cream treating tinea pedis. Methods; 94 patients with tinea pedis, were randomly divided into treatment group and control group. Treatment group oral Itraconazole Capsules combined with external use 2% ketoconazole cream treating 47 patients with tinea perils,the total course of 4 weeks. Control group external use 2% ketoconazole cream treating 47 patients with tinea pedis,the total course of 4 weeks. Observe two groups of patients with drug use 2 weeks,4 weeks and after discontinuation 2 weeks of clinical curative effect and mycology curative effect and adverse reactions. Results; Two groups of patients with drug use 2 weeks the effective rate were 25.5 %and 17.0 % respectively, the fungus eradication rate were 34.0 % and 23.4 % respectively. There was no statistically significant difference comparing the two groups（P 〉 0. 05）. Two groups of patients with drug use 4 weeks the effective rate were 61. 7 % and 40.4 % respectively,the fungus eradication rate were 72.3 % and 46.8 % respectively. Comparative differences between the two groups have statistical significance（P〈0.05）. Two groups patients after discontinuation 2 weeks of the effective rate were 80.9% and 55.3% respectively, the fun- gus eradication rate were 91.5 % and 61.7 % respectively. Comparative differences between the two groups have statistical significance（P〈0.05）. Two groups of patients with no serious adverse reaction after taking this medicine. Conclusion： Oral Itraconazole Capsules combined with external use 2 ketoconazole cream in the treatment of tinea pedis clinical curative effect and mycology curative effect is good,Side effects are less.

关 键 词：伊曲康唑胶囊 2%酮康唑乳膏 足癣 

分 类 号：R751[医药卫生—皮肤病学与性病学]