抗菌药物临床应用专项整治后呼吸内科抗菌药物使用分析  

Use of antibiotics in respiratory medicine department after special rectification of clinical application of antibiotics

作　　者：毛小红[1] 俞佳[1] 祁金文[1] 谢丹[1] 

机构地区：[1]浙江省人民医院药学部,浙江杭州310014

出　　处：《中华医院感染学杂志》2013年第21期5272-5274,共3页Chinese Journal of Nosocomiology

基　　金：浙江省卫生厅科研计划基金项目(2008B119)

摘　　要：目的了解呼吸内科抗菌药物使用情况,为继续深入开展抗菌药物临床应用整治工作提供数据。方法抽取呼吸内科2012年7月126份出院病历,分析患者临床资料和抗菌药物使用情况,评价抗菌药物使用的合理性。结果 126份病历中有116份使用抗菌药物,抗菌药物使用率92.06%;主要疾病为社区获得性肺炎、慢性阻塞性肺疾病急性发作和支气管扩张伴感染;病原菌送检率93.10%;抗菌药物总使用强度为166.68;联合使用抗菌药物共13例,联合用药率为11.21%;抗菌药物使用约50.00%为限制使用级抗菌药物,占总抗菌药物使用频度的50.51%;抗菌药物以静脉制剂为主,占总抗菌药物使用频度的78.46%;氟喹诺酮类、头孢菌素类和β-内酰胺酶抑制剂合剂为最常使用类别,使用率分别为37.74%、33.96%和13.06%;使用频度最高的抗菌药物品种为莫西沙星、头孢曲松和头孢吡肟。结论呼吸内科抗菌药物使用较规范合理,但仍存在一些问题有待改进。OBJECTIVE To investigate the use of antibiotics in respiratory medicine department so as to provide evidence for further conducting the special rectification of clinical application of antibiotics. METHODS The medical records of 126 patients who were discharged from the respiratory medicine department in Jul 2012 were retrospectively reviewed, then the clinical data and the use of antibiotics were analyzed, and the rationality of the use of antibiotics was assessed. RESULTS Of totally 126 patients investigated, 116 cases have used antibiotics with the utilization rate of 92.06 %. The major diseases included the community-acquired pneumonia, acute exacerbation of chronic obstructive pulmonary disease, and bronchiectasis complicated with infection. The submission rate of pathogens was 93.10% the antibiotics use density was 166.68; totally 13 cases received the combination use of antibiotics with the combination medication rate of 11. 21%; 50. 00% of the cases have used the restricted antibiotics, accounting for 50. 51% among the total antibiotics use density; the intravenous administration of injections was dominant, accounting for 78. 46% among the total antibiotics use density; the fluoroquinolones （37.74%）, cephalosporins （33.96%） and beta-lactamase inhibitors mixture （13.06%） were the most frequently used sorts; the moxifloxacin, ceferiaxone, and cefepime ranked the top three DDDs. CONCLUSION The use of antibiotics is basically reasonable in the respiratory medicine department, but some problems remain and need to be improved.

关 键 词：呼吸内科 抗菌药物 合理用药 

分 类 号：R978.1[医药卫生—药品]