阿苯达唑对自发性兔脑炎原虫病的治疗  

Albendazole treatment for rabbit spontaneously infected with Encephalitozoon cuniculi

作　　者：潘耀谦[1] 刘兴友[1] 冯春花[2] 赵振升[3] 李瑞珍[1] 刘志科[1] 李会珍[1] 孙玉倩[1] 

机构地区：[1]河南科技学院动物疫病和残留物防控河南省高校工程技术研究中心,河南新乡453003 [2]新乡市动物疫病预防控制中心 [3]河南科技大学动物科技学院,河南洛阳471003

出　　处：《中国兽医学报》2013年第11期1758-1761,1767,共5页Chinese Journal of Veterinary Science

基　　金：教育部留学回国人员科研启动基金资助项目(2004527);河南科技学院人材科学研究基金资助项目(200901)

摘　　要：为了有效地治疗兔脑炎原虫病,本研究根据脑炎原虫的生物学特点和对组织损伤的特征选用阿苯达唑进行了治疗试验。将28只3～4月龄隐性感染的獭兔,随机分为对照组和治疗组进行试验。治疗组按30mg/kg剂量(首次给药量为50mg/kg),每隔12h给药1次,连续用药10d,停药1周为1个治疗期,共治疗3个疗程。对照组按正常饲养。每1疗程之后,均采血和尿液进行ELISA检测和尿沉渣虫体检查。结果,治疗组的病兔用阿苯达唑治疗3个疗程后,ELISA检测的D值均低于标准值(<0.044),即抗脑炎原虫血清抗体呈阴性反应,从尿沉渣中也不能检出虫体。而对照组病兔的D值则大大高于正常值,从尿沉渣中均易检出虫,并有1只对照兔出现典型的神经症状,剖检后从脑组织中检出脑炎原虫性肉芽肿。经方差分析,2组间差异非常显著(P<0.01)。试验证明,阿苯达唑对兔脑炎原虫有良好治疗作用,用药的时机以脑炎原虫还未进入脑组织时最合适,用药的剂量一定要保持有效的杀虫浓度。To treat encephalitozoonosis effectively,the drug,albendazole was chosen at this experi- men＊ according to biological characters of parasites and tissue lesions caused by Encepha/ilozoon cuniculi. Twenty eight recessive infectious rex rabbits （3 4 months old） were divided into control group and treating group randomly. Treating group was cured by albendazole with a dose of 30 mg/kg（first time was 50 mg/kg）,at 12 h intervals,and continuously cured for 10 treatment for 10d as one treatment period and treated with 3 treat-ment period ahoge group was feed as normal. After one treating period the blood and urine were co d, then stop ther. Control lected for ELISA assay and urinary sediment examination of Encephalitozoon cuniculi. Results proved that after sick rabbits were treated for three period, its D value of ELISA assay was lower than standard value （〈-0. 044）,and the polypides were not examined in urinary sediment. Contrary,D value of sick rabbits in control group was greatly higher than standard value, the parasites were easily ex- amined iu the urinary sediment. Only one rabbit in control group appeared neurological symptoms and encephalitozoonic granuloma was examined in brain tissue after autopsy. The difference was very significant between two groups by variance analysis （P〈0. 01）. The experiment proves that the albendazole has good therapeutic effeet on Encephalitozoon cuniculi, the suitable timing of u- sing drug is that the parasites do not enter into the brain tissues and the dose of drug must be maintained in the effective insecticidal concentration.

关 键 词：兔脑炎原虫 兔脑炎原虫病 阿苯达唑 治疗研究 

分 类 号：S852.72[农业科学—基础兽医学]