奥扎格雷钠联合疏血通注射液治疗急性脑梗死的荟萃分析  

Meta Analysis of Shuxuetong Injection Combined with Ozagrel Sodium in Treatment of Acute Cerebral Infarction

作　　者：王莉梅[1] 刘行梅[2] 姚铭[1] 付秀娟[2] 金向群[3] 

机构地区：[1]吉林大学第四医院,长春130011 [2]吉林大学第二医院,长春130011 [3]吉林大学药学院,长春130011

出　　处：《中国实验方剂学杂志》2013年第20期319-324,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：吉林省科学技术厅自选项目(2013042)

摘　　要：目的:评价奥扎格雷钠联合疏血通注射液治疗急性脑梗死的疗效和安全性。方法:通过计算机在线检索已经公开发表的关于奥扎格雷钠联合疏血通注射液治疗急性脑梗死的临床随机对照试验的相关文献,结合纳入文献中两组的总有效率、神经功能缺损评分等数据,并应用Review Manager 5.1.7做Meta分析。结果:共纳入24个随机对照试验。分析显示,奥扎格雷钠联合疏血通注射液治疗急性脑梗死的神经功能缺损临床疗效比值比(OR)合并值为4.30(95%可信区间为3.16~5.86)。神经功能缺损评分疗效加权均数差(WMD)合并值为-3.63(95%可信区间为-4.85^-2.41)。结论:奥扎格雷钠联合疏血通注射液治疗急性脑梗死临床疗效确切,未见明显不良反应,但仍需要更多严格、多中心的随机双盲对照试验提供有力证据。Objective：It is to assess the curative effect and safety of Shuxuetong injection combined with Ozagrel Sodium injection in the treatment of acute cerebral infarction （ACI） with Meta analysis method.Method：The randomized controlled clinical trials of Shuxuetong injection combined with Ozagrel Sodium injection for the treatment of ACI from 1989-2012 were searched by computer-based on line search,and the data was statistically analyzed by Review Manager 5.1.7.Result：The results showed that there were 24 literatures which incorporated by Meta-analysis and the criterion were homogenous.Fixed effect model statistics and analysis showed that the OR （95％CI） was 4.30 （3.16-5.86）.WMD （95％ CI） was-3.63 （-4.85--2.41）.Conclusion：Meta analysis shows that Shuxuetong combined with Ozagrel Sodium injection is effective for ACI and it can improve the clinlcal symptom and neurologic impairment in the treatment of ACI without obvious ADR.However,more strict and multicentric randomized double-blind control trials are needed in order to provide more convinced evidence.

关 键 词：奥扎格雷钠 疏血通注射液 急性脑梗死 META分析 

分 类 号：R287[医药卫生—中药学]