百草枯中毒治疗的新策略——干细胞移植  

A new strategy for the treatment of paraquat poisoning——stem cell transplantation

作　　者：张拥军[1] 侯云生(审校)[1] 

机构地区：[1]白求恩国际和平医院急诊科,河北石家庄050082

出　　处：《中国急救医学》2013年第10期886-888,共3页Chinese Journal of Critical Care Medicine

摘　　要：百草枯（PQ）中毒患者病死率极高,在临床上该病尚无特效解毒药物,常规的血液净化疗效并不显著,因此寻找新的百草枯中毒的治疗方法尤为重要.百草枯中毒的确切毒性机制尚不清楚,但其主要的分子机制是基于氧化还原系统及细胞内所产生的氧化应激反应.血液灌流是当前治疗百草枯中毒的有效方法,但其对百草枯所造成的肺损伤临床疗效极为有限.近年来,干细胞被广泛应用于治疗氧化应激相关疾病,特别是国内外学者通过干细胞移植有效地改善了百草枯所致的鼠肺损伤,这为百草枯中毒治疗带来了新的曙光.The mortality of patients with paraquat poisoning is high. So far there is no specific treatment because the exact mechanism of paraquat poisoning is unclear; its molecular mechanism is mainly based on the redox system and oxidative stress generated within cells. In recent years, stem cells have been widely used in the treatment of diseases associated with oxidative stress. Scholars at home and abroad have proved that stem cell transplantation can effectively improve the rat lung injury - induced by paraquat, which bring us a new hope for the paraquat poisoning treatment.

关 键 词：百草枯(PQ) 氧化应激 干细胞治疗 机制 

分 类 号：R595.4[医药卫生—内科学]