苦参碱抗肿瘤作用机制研究进展  

Advance in studies on anti-tumor mechanism of matrine

作　　者：郭林丰 童姗姗[1] 余江南[1] 徐希明[1] 

机构地区：[1]江苏大学药学院,江苏镇江212013

出　　处：《中国中药杂志》2013年第20期3409-3412,共4页China Journal of Chinese Materia Medica

摘　　要：苦参碱是中药苦参、山豆根、苦豆子的主要活性成分之一。近年来,苦参碱的抗肿瘤活性受到广泛关注。研究表明苦参碱通过诱导细胞凋亡、细胞周期阻滞、诱导细胞自噬、抑制肿瘤细胞转移和侵袭、抑制血管生成、抑制NF-κB表达等多途径发挥抗肿瘤作用,并能与化疗药物协同作用。随着苦参碱抗肿瘤作用机制的进一步阐明,其在肿瘤临床治疗中将具有广阔的开发应用前景。Matrine is one of the main active components extracted from Sophoraflavescens, S. subprostrata and S. alopecu- roides. In recent years, its anti-tumor activity has attracted wide attention. According to studies, matrine shows the anti-tumor effect through multiple channels such as inducing apoptosis and autophagy of cancer cells, arresting cell cycle, inhibiting tumor cell migra- tion, angiogenesis and NF-KB, as well as the synergistic effect with chemotherapeutics. Along with the further studies on matrine＇s an- ti-tumor mechanism, it has a broad prospect for development and application in tumor clinical treatment.

关 键 词：苦参碱 抗肿瘤 作用机制 

分 类 号：R285.5[医药卫生—中药学]