帕金森病的中医证型分布及中医药治疗方药文献分析  

An Analysis of TCM Pattern and Formula for Parkinson's Disease

作　　者：魏维[1] 蔡晶[2] 

机构地区：[1]福建中医药大学第二临床医学院 [2]福建中医药大学中西医结合研究院

出　　处：《中医杂志》2013年第20期1778-1782,共5页Journal of Traditional Chinese Medicine

基　　金：福建省自然科学基金资助项目(2009J06018)

摘　　要：目的通过文献研究探讨帕金森病(PD)的中医证型分布和用药规律。方法检索维普科技期刊全文数据库、万方数据库、中国知网,纳入中医、中西医结合治疗PD的随机对照临床研究类文献,对符合标准文献中的证型、药物、药物功效、药物归经进行频率和聚类分析。结果共纳入符合标准文献116篇,涉及证型14个,其中肝肾阴虚型的频率最高,占55.2%,较其他证型所占比例差异均有统计学意义(P<0.01)。涉及药物140种,使用药物总频率为1 102,常用药物为白芍、何首乌、山茱萸、当归、熟地黄、川芎、天麻、龟甲、丹参、僵蚕、钩藤、全蝎。140种药物按功效分为31类,常用类别为补血药、平肝熄风药、活血药、补阴药、补气药、补肾固精药、补阳药、清热凉血药、平抑肝阳药、开窍药,其中补血药、平肝熄风药、活血药使用频次分别和其他类别比较差异有统计学意义(P<0.01)。140种药物归经分布差异有统计学意义(P<0.01),肝经所占比例较其他经差异有统计学意义(P<0.05)。结论 PD的证型以肝肾阴虚为主,用药规律以补肾柔肝、活血化瘀为主。Objective To explore the pattern distribution and formula law of Chinese medicine for Parkinson＇s disease （PD） according to literature study. Methods The articles of randomized controlled clinical studies on Chinese medicine and integrative medicine for PD were searched from VIP database, Wanfang database and China National Knowledge Infrastructure （CNKI）. The frequency and cluster analysis was applied to analyze the pattern, medicinal, efficacy and channel entry of medicinal. Results Totally 116 articles were included and 14 patterns were involved. The most frequent pattern was liver- kidney yin deficiency pattern and it accounted for 55.2%, with a significant difference between other patterns （P〈0.01）. Totally 140 kinds of medicinal were involved and the overall frequency of medicinal application was 1 102. The commonly used herbs were Baishao （Radix Paeoniae Alba ）, Heshouwu （Radix Polygoni Multiflori ）, Shanzhuyu （Frucgus Corni ）, Danggui （Radix Angelicae Sinensis ） , Shudihuang （ Radicr Rehmanniae Praeparata ）, Chuanxiong （ Rhizoma Chuanxiong ） , Tianma （Rhizoma Gastrodiae ）, Guijia （Carapax et Plastrum Testudinis ）, Danshen （Radix et Rhizoma Salviae Miltiorrhizae ）, Jiangcan （Bombyx Batryticatus）, Gouteng （Ramulus Uncariae Cure Uncis） and Quanxie （Scorpio）. One hundred and forty kinds of medicinal could be divided into 31 categories according to efficacy. The commonly used medicinal categories were blood-supplementing medicinal, liver-calming wind-extinguishing medicinal, blood-quickening medicinal, yin-supplementing medicinal, qi-supplementing medicinal, kidney supplementing essence-securing medicinal, yang-supplementing medicinal, heat- clearing blood-cooling medicinal, liver-repressing medicinal and orifice-opening medicinal, especially blood-supplementing medicinal, liver-calming wind-extinguishing medicinal and blood-quickening medicinal （P〈0.01）. There were significant differences in the distribution of channel entry of 140 herbs �

关 键 词：帕金森病 证候分型 方药分析 文献研究 

分 类 号：R277.7[医药卫生—中医学]