丹参酮ⅡA磺酸钠联合二磷酸果糖对新生儿缺氧缺血性脑病患儿超敏C反应蛋白及脂联素水平的影响  

Effects of tanshinone ⅡA sodium sulfonate combined with1,6 diphosphate fructose on high-sensitivity C-reactive protein and adiponectin levels in neonatal hypoxic-ischemic encephalopathy children patients

作　　者：钱烘云 李娅凤[2] 

机构地区：[1]绍兴市第二医院儿科,浙江绍兴321000 [2]绍兴市妇幼保健院新生儿科,浙江绍兴321000

出　　处：《中国医院药学杂志》2013年第20期1692-1694,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:探讨丹参酮ⅡA磺酸钠联合二磷酸果糖对新生儿缺氧缺血性脑病患儿超敏C反应蛋白及脂联素水平的影响。方法:选取2010年10月-2012年10月收治的新生儿缺氧缺血性脑病患儿72例,随机将患儿分为丹参酮组,二磷酸果糖组及联合用药组,每组24例。另选同期收治的健康儿童30例作为对照组。比较分析缺养缺血患儿治疗前后超敏C反应蛋白和脂联素水平的变化情况,患儿心率和心电图恢复正常时间以及治疗过程中不良反应的发生情况。结果:与对照组新生儿相比,其他3组缺氧缺血性脑病患儿hs-CRP水平明显提高,而APN水平明显降低,差异均具有统计学意义(P<0.05)。与治疗前患儿相比,治疗后丹参酮组、二磷酸果糖组及联合用药组患儿hs-CRP水平明显降低,而仅联合用药组患儿APN水平明显提高,差异均具有统计学意义(P<0.05)。与联合用药组患儿相比,单用药丹参酮组和二磷酸果糖组患儿心率和心电图恢复正常的时间明显延长,差异均具有统计学意义(P<0.05)。3组患儿在治疗过程中均无明显的不良反应发生。结论:丹参酮ⅡA磺酸钠联合二磷酸果糖可作为新生儿缺氧缺血患儿合理的联合用药方案做进一步临床推广。OBJECTIVE To investigate the effects of tanshinone Ⅱ A sodium sulfonate combined with 1,6 diphosphate fruc tose on high-sensitivity Oreactive protein and adiponectin levels in neonatal hypoxic-ischemic encephalopathy children patients. METHODS 72 neonatal hypoxic-ischemic encephalopathy children patients were selected from October 2010 to October 2012. The children patients were divided into of tanshinone ⅡA sodium sulfonate group, 1 ,6 diphosphate fructose group and corn bined treatment group randomly. There were 24 cases in each group. 30 cases of healthy children were selected as control group. The changes of the high sensitivity C reactive protein and adiponectin levels before and after the treatment, the time of heart rate and electrocardiogram resuming normal time, and the incidence of adverse reactions in the course of treatment were compared and analyzed. RESULTS Compared with the control group, the children patients in other groups, the levels of hs CRP were increased significantly, the levels of APN were lowered significantly, there were statistically significant difference （P 〈0. 05）. Compared with before treatment, after treatment the children patients in tanshinone group, diphosphate group and combined treatment group the levels of hs CRP were lowered significantly, but only the children patients in combined treatment group the levels of APN were increased significantly, there were statistically significant difference （P〈0.05）. Compared with combined treatment group, the children patients in tanshinone group and diphosphate group the time of heart rate and electro cardiogram returned to normal was prolonged, there were statistically significant difference （P〈0. 05）. CONCLUSION Tan shinone I1 A sodium sulfonate combined with 1,6 diphosphate fructose could be taken as the reasonable combinatkm regimens for neonatal hypoxic-ischemic encephalopathy children patients in clinic.

关 键 词：新生儿 缺氧缺血性脑病 丹参酮ⅡA磺酸钠 二磷酸果糖 超敏C反应蛋白 脂联素 

分 类 号：R969[医药卫生—药理学]