吡唑并嘧啶酮的合成进展  

Progress in Synthesis of Pyrazolopyrimidinone

作　　者：杨绪红[1] 曹晓蓓[1] 金小红[1] 吴鸣虎[1] 

机构地区：[1]湖北科技学院核技术与化学生物学院,咸宁437100

出　　处：《有机化学》2013年第10期2080-2097,共18页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21202136)资助项目~~

摘　　要：吡唑并嘧啶酮化合物广泛存在于自然界.自从1888年合成第一个吡唑并嘧啶酮以来,吡唑并嘧啶酮的合成与应用研究越来越活跃.一些吡唑并嘧啶酮化合物被应用到常见疾病的治疗上,可谓珍贵药物发现史上的明珠.一个多世纪以来,各种合成吡唑嘧啶酮化合物的方法层出不穷.但是,有关吡唑嘧啶酮的合成的专题综述尚未见文献报道.本文从合成方法学的角度对吡唑并嘧啶酮的合成作一全面综述.Pyrazolopyrimidinone compounds are widely found in nature. Since the first pyrazolopyrimidinone was synthe- sized in 1888, synthesis and application of pyrazolopyrimidinones have been more and more active. Some pyrazolopyrimidi- nones are applied to the treatment of commom diseases, and are called the crown jewels in drug discovery history. For more than one century, various synthetic methodologies concerning pyrazolopyrimidinone have been developed. However, no spe- cific review about pyrazolopyrimidinones was present. This review comments the synthesis of pyrazolopyrimidinone from the point of view of the synthetic methodology.

关 键 词：1H-吡唑并[3 4-棚嘧啶-4(5 )-酮 1H-吡唑并[3 4-堋嘧啶-6(7H)-酮 1H-NL吡唑并[4 3-加嘧啶-5(4H)-酮 lH吡唑并[4 3-切嘧啶-7(6H)-酮 吡唑并嘧啶酮 合成 

分 类 号：O626[理学—有机化学]