5-胺基-2-氧代-7-芳基-2,3,4,7-四氢-1,3-噻唑并[4,5-b]吡啶-6-甲酰胺类化合物的微波合成  

Synthesis of 5-Amino-2-oxo-7-aryl-2,3,4,7-tetrahydro- 1,3-thiazolo[4,5-b]pyridine-6-carboxamide Derivatives under Microwave Irradiation

作　　者：孙宏顺[1,2] 王建强[1] 郭成[1] 沈临江[1] 

机构地区：[1]南京工业大学理学院,南京211816 [2]南京化工职业技术学院化学工程系,南京210048

出　　处：《有机化学》2013年第10期2220-2225,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学青年基金(No.21106069);南京化工职业技术学院院级重点(No.NHKY-2013-2)资助项目~~

摘　　要：以芳亚甲基丙二腈、2,4-噻唑烷二酮和醋酸铵为原料,在微波辐射条件下,合成得到5种未见文献报道的5-胺基-2-氧代-7-芳基-2,3,4,7-四氢-1,3-噻唑并[4,5-b]吡啶-6-甲酰胺系列化合物.发现微波辐射条件下与传统加热条件下所得产物5-胺基-2-氧代-7-芳基-2,3,4,7-四氢-1,3-噻唑并[4,5-b]吡啶-6-甲腈不同,并对反应机理进行了探讨.所有新化合物结构均经1H NMR,IR,MS和元素分析确证.Abstract Five new 5-amino-2-oxo-7-aryo-2,3,4,7-tetrahydro-oo3-thiazolo[4o5-b]pyridine-6-carboxamide derivatives, which are different with the products of 5-amino-2-oxo-7-aryo-2o3o4o7otetrahydro-l,3-thiazo1o[4,5-b]pyridine-6-carbonitrioe deriva- tives in the conventional heating conditions, were synthesized by using arylmethylene malononitrile, 2,4-thiazolidinedione and ammonium acetate in one-pot via microwave irradiation techniques. And the reaction mechanism was discussed. The struc- tures of these compounds were characterized by 1H NMR, IR, MS and elemental analysis.

关 键 词：2 4-噻唑烷二酮 噻唑并[4 5—6]吡啶 微波 合成 

分 类 号：O626[理学—有机化学]